Gene Review:
RALBP1 - ralA binding protein 1
Homo sapiens
Synonyms:
76 kDa Ral-interacting protein, DNP-SG ATPase, Dinitrophenyl S-glutathione ATPase, RIP, RIP1, ...
Yadav,
Sharma,
Bandorowicz-Pikula,
Singhal,
Cucullo,
Awasthi,
Singhal,
Awasthi,
Cubre,
Wickramarachchi,
John,
Dwivedi,
Awasthi,
Drake,
Awasthi,
Jarman,
Saini,
Singhal,
Cheng,
Awasthi,
Yadav,
Fazio,
Bidere,
Awasthi,
Singhal,
Zimniak,
Zimniak,
Awasthi,
Awasthi,
Singh,
Awasthi,
Singhal,
Singhal,
Awasthi,
Staudt,
Zimniak,
Zheng,
Zajac,
Lenardo,
Pikula,
Awasthi,
Rowe,
Singhal,
Boor,
Janigro,
Dent,
Orenstein,
Yang,
Singhal,
Dini,
Chan,
Nadkar,
Awasthi,
Pandya,
Singhal,
Hallene,
Drake,
Yacoub,
- Doxorubicin transport by RALBP1 and ABCG2 in lung and breast cancer. Singhal, S.S., Singhal, J., Nair, M.P., Lacko, A.G., Awasthi, Y.C., Awasthi, S. Int. J. Oncol. (2007)
- RALBP1/RLIP76 mediates multidrug resistance. Drake, K.J., Singhal, J., Yadav, S., Nadkar, A., Pungaliya, C., Singhal, S.S., Awasthi, S. Int. J. Oncol. (2007)
- Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin. Awasthi, S., Cheng, J., Singhal, S.S., Saini, M.K., Pandya, U., Pikula, S., Bandorowicz-Pikula, J., Singh, S.V., Zimniak, P., Awasthi, Y.C. Biochemistry (2000)
- The role of PKCalpha and RLIP76 in transport-mediated doxorubicin-resistance in lung cancer. Singhal, S.S., Yadav, S., Singhal, J., Drake, K., Awasthi, Y.C., Awasthi, S. FEBS Lett. (2005)
- Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1. Singhal, S.S., Yadav, S., Drake, K., Singhal, J., Awasthi, S. J. Biol. Chem. (2008)
- Transport functions and physiological significance of 76 kDa Ral-binding GTPase activating protein (RLIP76). Awasthi, S., Sharma, R., Yang, Y., Singhal, S.S., Pikula, S., Bandorowicz-Pikula, J., Singh, S.V., Zimniak, P., Awasthi, Y.C. Acta Biochim. Pol. (2002)
- Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Ea, C.K., Deng, L., Xia, Z.P., Pineda, G., Chen, Z.J. Mol. Cell (2006)
- Adenosine triphosphate-dependent transport of doxorubicin, daunomycin, and vinblastine in human tissues by a mechanism distinct from the P-glycoprotein. Awasthi, S., Singhal, S.S., Srivastava, S.K., Zimniak, P., Bajpai, K.K., Saxena, M., Sharma, R., Ziller, S.A., Frenkel, E.P., Singh, S.V. J. Clin. Invest. (1994)
- RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics. Awasthi, S., Sharma, R., Singhal, S.S., Zimniak, P., Awasthi, Y.C. Drug Metab. Dispos. (2002)
- RLIP76, a non-ABC transporter, and drug resistance in epilepsy. Awasthi, S., Hallene, K.L., Fazio, V., Singhal, S.S., Cucullo, L., Awasthi, Y.C., Dini, G., Janigro, D. BMC neuroscience [electronic resource]. (2005)
- Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay. Bogerd, H.P., Fridell, R.A., Benson, R.E., Hua, J., Cullen, B.R. Mol. Cell. Biol. (1996)
- Identification of membrane-anchoring domains of RLIP76 using deletion mutant analyses. Yadav, S., Singhal, S.S., Singhal, J., Wickramarachchi, D., Knutson, E., Albrecht, T.B., Awasthi, Y.C., Awasthi, S. Biochemistry (2004)
- POB1 over-expression inhibits RLIP76-mediated transport of glutathione-conjugates, drugs and promotes apoptosis. Yadav, S., Zajac, E., Singhal, S.S., Singhal, J., Drake, K., Awasthi, Y.C., Awasthi, S. Biochem. Biophys. Res. Commun. (2005)
- RLIP76 is a major determinant of radiation sensitivity. Awasthi, S., Singhal, S.S., Yadav, S., Singhal, J., Drake, K., Nadkar, A., Zajac, E., Wickramarachchi, D., Rowe, N., Yacoub, A., Boor, P., Dwivedi, S., Dent, P., Jarman, W.E., John, B., Awasthi, Y.C. Cancer Res. (2005)
- Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): a novel link between G-protein and tyrosine kinase signaling and drug resistance. Awasthi, S., Singhal, S.S., Sharma, R., Zimniak, P., Awasthi, Y.C. Int. J. Cancer (2003)
- Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. Nakashima, S., Morinaka, K., Koyama, S., Ikeda, M., Kishida, M., Okawa, K., Iwamatsu, A., Kishida, S., Kikuchi, A. EMBO J. (1999)
- Competitive control of independent programs of tumor necrosis factor receptor-induced cell death by TRADD and RIP1. Zheng, L., Bidere, N., Staudt, D., Cubre, A., Orenstein, J., Chan, F.K., Lenardo, M. Mol. Cell. Biol. (2006)
- Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. Ikeda, M., Ishida, O., Hinoi, T., Kishida, S., Kikuchi, A. J. Biol. Chem. (1998)
- RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis. Rossé, C., L'Hoste, S., Offner, N., Picard, A., Camonis, J. J. Biol. Chem. (2003)
- The post-translational modifications of Ral and Rac1 are important for the action of Ral-binding protein 1, a putative effector protein of Ral. Matsubara, K., Hinoi, T., Koyama, S., Kikuchi, A. FEBS Lett. (1997)
- RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes. Sharma, R., Singhal, S.S., Cheng, J., Yang, Y., Sharma, A., Zimniak, P., Awasthi, S., Awasthi, Y.C. Arch. Biochem. Biophys. (2001)
- Linking stress-signaling, glutathione metabolism, signaling pathways and xenobiotic transporters. Yadav, S., Zajac, E., Singhal, S.S., Awasthi, S. Cancer Metastasis Rev. (2007)
- Triad3A Regulates Ubiquitination and Proteasomal Degradation of RIP1 following Disruption of Hsp90 Binding. Fearns, C., Pan, Q., Mathison, J.C., Chuang, T.H. J. Biol. Chem. (2006)
- RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis. Jullien-Flores, V., Mahé, Y., Mirey, G., Leprince, C., Meunier-Bisceuil, B., Sorkin, A., Camonis, J.H. J. Cell. Sci. (2000)
- RLIP76 (RALBP1)-mediated transport of leukotriene C4 (LTC4) in cancer cells: implications in drug resistance. Sharma, R., Singhal, S.S., Wickramarachchi, D., Awasthi, Y.C., Awasthi, S. Int. J. Cancer (2004)
- A serine kinase associates with the RAL GTPase and phosphorylates RAL-interacting protein 1. Jilkina, O., Bhullar, R.P. Biochim. Biophys. Acta (2006)
- Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress. Cheng, J.Z., Sharma, R., Yang, Y., Singhal, S.S., Sharma, A., Saini, M.K., Singh, S.V., Zimniak, P., Awasthi, S., Awasthi, Y.C. J. Biol. Chem. (2001)
- Low and high Km forms of dinitrophenylglutathione-stimulated ATPase in bovine lens. Kumari, K., Ansari, N.H., Saxena, M., Awasthi, Y.C., Srivastava, S.K. Exp. Eye Res. (1993)
- Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity. Awasthi, S., Singhal, S.S., Singhal, J., Yang, Y., Zimniak, P., Awasthi, Y.C. Int. J. Oncol. (2003)
- Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells. Singhal, S.S., Singhal, J., Sharma, R., Singh, S.V., Zimniak, P., Awasthi, Y.C., Awasthi, S. Int. J. Oncol. (2003)