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Gene Review

QRFPR  -  pyroglutamylated RFamide peptide receptor

Homo sapiens

Synonyms: AQ27, G-protein coupled receptor 103, GPR103, Orexigenic neuropeptide QRFP receptor, Pyroglutamylated RFamide peptide receptor, ...
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Disease relevance of GPR103

  • Altogether, these results suggest that osteopenia in GPR103-/- mice may be mediated directly by the loss of GPR103 expression in bone [1].

High impact information on GPR103


Anatomical context of GPR103


  1. The G-protein-coupled receptor GPR103 regulates bone formation. Baribault, H., Danao, J., Gupte, J., Yang, L., Sun, B., Richards, W., Tian, H. Mol. Cell. Biol. (2006) [Pubmed]
  2. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S.C., Iguchi, H., Kawasawa, Y.I., Ikeda, Y., Sakakibara, I., Ohno, K., Ioka, R.X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T., Ohuchi, T., Yanagisawa, M., Sakai, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Discovery and mapping of ten novel G protein-coupled receptor genes. Lee, D.K., Nguyen, T., Lynch, K.R., Cheng, R., Vanti, W.B., Arkhitko, O., Lewis, T., Evans, J.F., George, S.R., O'Dowd, B.F. Gene (2001) [Pubmed]
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