Gene Review:
BTBD10 - BTB (POZ) domain containing 10
Homo sapiens
Synonyms:
BTB/POZ domain-containing protein 10, GMRP-1, GMRP1, Glucose metabolism-related protein 1, MGC13007
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Disease relevance of BTBD10
- All these data suggested that BTBD10 might play a role in glioma [1].
- We also investigated the expression of BTBD10 in hepatocellular carcinoma, ovary cancer and lung cancer, and the results revealed no significant difference in these three tumors [1].
High impact information on BTBD10
- The different expression patterns of BTBD10 in different grades of glioma versus normal brain were also examined by RT-PCR and Northern blot [1].
- The subcellular localization result revealed that BTBD10 was located specifically in the nucleus of HEK293 and COS7 cell lines, suggesting that it may function in transcriptional regulation [1].
- From a fetal brain cDNA library, we isolated a cDNA of 2489 base pairs (bp) encoding a novel human BTB domain-containing protein named BTBD10 [1].
- The BTBD10 gene was located on human chromosome 11p15.2 and consisted of nine exons spanning about 75.2 kilobase pairs (kb) of the human genome [1].
- The expression pattern of BTBD10 gene was examined by multiple tissue cDNA (MTC) panels (Clontech), which showed a ubiquitous expression pattern in the 16 tissues examined with high expression in adult brain, testis and small intestine and weak expression in the heart, lung, liver, kidney, pancreas, spleen, thymus, prostate, ovary and colon [1].
Analytical, diagnostic and therapeutic context of BTBD10
- The cDNA microarray analysis showed that BTBD10 was down-regulated in all 18 glioma samples [1].
- Molecular cloning and characterization of a novel human BTB domain-containing gene, BTBD10, which is down-regulated in glioma [1].
References
- Molecular cloning and characterization of a novel human BTB domain-containing gene, BTBD10, which is down-regulated in glioma. Chen, J., Xu, J., Ying, K., Cao, G., Hu, G., Wang, L., Luo, C., Lou, M., Mao, Y., Xie, Y., Lu, Y. Gene (2004) [Pubmed]
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