High impact information on Cetn1

• Differential expression and interaction with the visual G-protein transducin of centrin isoforms in mammalian photoreceptor cells [1].
• Ca(2+)-triggered assembly of a centrin-transducin complex in the connecting cilium of photoreceptor cells may regulate these transducin translocations [1].
• Reverse transcriptase-polymerase chain reaction and Northern blot analysis demonstrate that Cetn1 expression is limited exclusively to the testis in adult male mice [2].
• Here, the mouse centrin 1 gene (Cetn1) is analyzed with respect to its genomic structure, chromosome localization, tissue-specific expression, and phylogenetic relationship to the other mouse centrin genes and their human orthologs [2].
• Testis-specific murine centrin, Cetn1: genomic characterization and evidence for retroposition of a gene encoding a centrosome protein [2].

Biological context of Cetn1

• Cetn1 expression is first seen in the neonatal testis at 14 days postpartum, reaching adult levels by day 17 [2].
• Cetn1 possesses the sequence features of an expressed retroposon: the gene lacks introns, the open reading frame is not interrupted by stop codons, and the coding region is flanked by a pair of direct repeats [2].

References