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Gene Review

Cetn1  -  centrin 1

Mus musculus

Synonyms: Calt, Caltractin, Centrin-1
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Disease relevance of Cetn1


High impact information on Cetn1


Biological context of Cetn1


Anatomical context of Cetn1


Associations of Cetn1 with chemical compounds


Other interactions of Cetn1

  • Cetn2 encodes a 172 amino acid protein, with a predicted molecular mass of 19,795 Da (pI=4.71), that contains all of the defining characteristics of centrin [7].
  • The assembly of centrin-G-protein complex is mediated by the betagamma-complex [3].
  • The striated bands of Paramecium are immunologically distinct from the centrin-specific infraciliary lattice and cytostomal cord [9].
  • Double-label immunofluorescence with antibodies against gamma-tubulin, detyrosinated alpha-tubulin, and centrin showed that the TU-06 epitope is localized outside the basal body region [10].

Analytical, diagnostic and therapeutic context of Cetn1


  1. High level expression in Escherichia coli and characterization of the EF-hand calcium-binding protein caltractin. Weber, C., Lee, V.D., Chazin, W.J., Huang, B. J. Biol. Chem. (1994) [Pubmed]
  2. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. Dammermann, A., Merdes, A. J. Cell Biol. (2002) [Pubmed]
  3. Calcium-dependent assembly of centrin-G-protein complex in photoreceptor cells. Pulvermüller, A., Giessl, A., Heck, M., Wottrich, R., Schmitt, A., Ernst, O.P., Choe, H.W., Hofmann, K.P., Wolfrum, U. Mol. Cell. Biol. (2002) [Pubmed]
  4. Spindle-pole organization during early mouse development. Hiraoka, L., Golden, W., Magnuson, T. Dev. Biol. (1989) [Pubmed]
  5. Phosphatidyl-inositide signalling proteins in a novel class of sensory cells in the mammalian olfactory epithelium. Elsaesser, R., Montani, G., Tirindelli, R., Paysan, J. Eur. J. Neurosci. (2005) [Pubmed]
  6. Centriole and centrin degeneration during mouse spermiogenesis. Manandhar, G., Simerly, C., Salisbury, J.L., Schatten, G. Cell Motil. Cytoskeleton (1999) [Pubmed]
  7. Characterization of the X-linked murine centrin Cetn2 gene. Hart, P.E., Poynter, G.M., Whitehead, C.M., Orth, J.D., Glantz, J.N., Busby, R.C., Barrett, S.L., Salisbury, J.L. Gene (2001) [Pubmed]
  8. Identification of enzymatically active Ca2+/calmodulin-dependent protein kinase in centrosomes of hemopoietic cells. Pietromonaco, S.F., Seluja, G.A., Elias, L. Blood Cells Mol. Dis. (1995) [Pubmed]
  9. The striated bands of Paramecium are immunologically distinct from the centrin-specific infraciliary lattice and cytostomal cord. Allen, R.D., Aihara, M.S., Fok, A.K. J. Eukaryot. Microbiol. (1998) [Pubmed]
  10. Distinct localization of a beta-tubulin epitope in the Tetrahymena thermophila and Paramecium caudatum cortex. Libusová, L., Sulimenko, T., Sulimenko, V., Janisch, R., Hozák, P., Dráber, P. Protoplasma (2005) [Pubmed]
  11. Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. Middendorp, S., Paoletti, A., Schiebel, E., Bornens, M. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
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