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Gene Review

ABHD14B  -  abhydrolase domain containing 14B

Homo sapiens

Synonyms: Abhydrolase domain-containing protein 14B, Alpha/beta hydrolase domain-containing protein 14B, CCG1-interacting factor B, CIB, HEL-S-299, ...
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Disease relevance of ABHD14B

  • It was concluded that CIBP patients do have abnormal physical findings indicative of musculoskeletal disease: possibly fibrositis and/or specific myofascial syndromes, as sources of peripheral nociception [1].
  • Because they did not fit the CIBP definition, patients with the following primary treatment diagnoses were eliminated: degenerative disease of the spine and spinal stenosis; degenerative disease of the hips; radiculopathy; malignancy; deafferentation pain; and miscellaneous [1].

High impact information on ABHD14B

  • Insight into the mechanisms of osteoblast and osteoclast activation, via receptor activator for nuclear factor KB (RANK) dependent and independent mechanisms and a re-evaluation of primary afferent terminals within bone have led to a suggestion that CIBP may be a mixture of inflammatory and neuropathic stimuli [2].
  • Coexpressed with CIBP, the antigen level of FVIII in the mammalian cell line baby hamster kidney (BHK) cells increased up to about 170% and its bioactivity rose accordingly [3].
  • A gene coding for a related protein of FVIII named calcium- and integrin-binding protein (CIBP) was isolated from the normal human liver cDNA library [3].

Analytical, diagnostic and therapeutic context of ABHD14B


  1. Physical findings in patients with chronic intractable benign pain of the neck and/or back. Rosomoff, H.L., Fishbain, D.A., Goldberg, M., Santana, R., Rosomoff, R.S. Pain (1989) [Pubmed]
  2. The pathophysiology of cancer-induced bone pain: current understanding. Urch, C. Palliative medicine. (2004) [Pubmed]
  3. The interaction of the calcium- and integrin-binding protein (CIBP) with the coagulation factor VIII. Fang, X., Chen, C., Wang, Q., Gu, J., Chi, C. Thromb. Res. (2001) [Pubmed]
  4. Purification, crystallization and preliminary X-ray crystallographic analysis of human CCG1-interacting factor B. Padmanabhan, B., Kuzuhara, T., Mizuno, H., Horikoshi, M. Acta Crystallogr. D Biol. Crystallogr. (2000) [Pubmed]
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