Disease relevance of Radiculopathy

• Clinical features attributed to her leptomeningeal amyloid included radiculopathy, central hypoventilation, recurrent subarachnoid haemorrhage, depression, seizures and periods of decreased consciousness [1].
• Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica [2].
• We randomly assigned 21 patients with painful Lyme neuroborreliosis radiculitis (Bannwarth's syndrome) and neuroborreliosis meningitis to a 10-day treatment with either penicillin G [3].
• METHODS: Thirty-seven patients underwent anterior cervical discectomy and fusion in which the DOC ventral cervical stabilization system was used for indications including cervical spondylotic radiculopathy, disc herniation, trauma, and myelopathy [4].
• METHODS: Fifty-three patients without prior back surgery, referred to our institution for evaluation of low-back pain and radiculopathy, were studied with gadolinium-enhanced MR (0.1 mmol/kg) of the lumbar spine [5].

Psychiatry related information on Radiculopathy

• Pain due to cauda equina injury, paraplegic pain, phantom-limb pain, pure midline back pain without radiculopathy, or pain due to primary bone or joint disease seemed to respond less well [6].

High impact information on Radiculopathy

• Demyelinating radiculopathy in the Kearns-Sayre syndrome: a clinicopathological study [7].
• In order to elucidate the pathophysiological mechanisms of painful radiculopathy, secondary to lumbar disc herniation, we evaluated pain-related behavior and the change of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) expression in the DRG and dorsal root using a rat model of lumbar disc herniation [8].
• CT without or with the use of intrathecal metrizamide was more accurate than myelography in the identification of lesions that caused cervical radiculopathy [9].
• Chordoma at the T-9 level, originally manifested by lumbosacral radiculopathy, developed in a 50-year-old man [10].
• Of these 12 patients (7 with radiculopathy and 5 with cauda equina syndrome), 9 received intrathecal hyperbaric lidocaine, 5% [11].

Chemical compound and disease context of Radiculopathy

• It is concluded that nerve root inflammation is the immediate cause of radicular symptoms in case of ruptured lumbar disc and that treatment with dexamethasone gives prompt relief of pain and may avoid the need for surgery in most cases [12].
• Cervical radiculopathy: open study on percutaneous periradicular foraminal steroid infiltration performed under CT control in 30 patients [13].
• This correlation is higher (73.3%) for the commonly occurring cervical radiculopathies (C6 and C7) [14].
• He presented with right C5 radiculopathy [15].
• An analysis of changes in distribution of substance P, methionine-enkephalin, and somatostatin after simulated nerve root avulsion injury suggested a possible mechanism for deafferentation pain [16].

Biological context of Radiculopathy

• Effects of diclofenac and ketoprofen on nerve conduction velocity in experimental nerve root compression [17].
• The H-reflex was recorded from the flexor carpi radialis, vastus medialis, and soleus muscles in patients with radiculopathy at C7, L4, and S1 roots [18].

Anatomical context of Radiculopathy

• Since the antipyretic and probably the analgesic effects of paracetamol are, at least in part, centrally mediated, its plasma and cerebrospinal fluid (CSF) concentrations were measured in 43 patients with nerve-root compression pain [19].
• The shortest pre- and postoperative distances between the anterolateral mid-edge of the spinal cord and dura-root junction were compared, using computed tomography-myelograms of postoperative C5 radiculopathies [20].
• However, pulmonary artery pressures were notably elevated (i.e., pulmonary hypertension) in those with COPD and nocturnal lumbosacral radiculopathy [21].
• Upper limb tension Test A was the most useful test for ruling out cervical radiculopathy [22].
• Effect of lumbar nerve root compression on primary sensory neurons and their central branches: changes in the nociceptive neuropeptides substance P and somatostatin [23].

Gene context of Radiculopathy

• IL-8 seems to participate in the pathomechanism of nerve root inflammation in lumbar disc herniations, which implies that it may be considered a target for therapeutic intervention [24].
• These results suggest that COX-2 and inflammatory cytokines might play a causative role in the radiculopathy of LDH through upregulating PGE2 synthesis [25].
• CONCLUSION: Among thoracolumbar junction disc herniations, T10-T11 and T11-T12 disc herniations were considered upper neuron disorders, T12-L1 disc herniations were considered lower neuron disorders, L1-L2 disc herniations were considered mild disorders of the cauda equina and radiculopathy, and L2-L3 disc herniations were considered radiculopathy [26].
• Twenty-seven patients presented with myelopathy, twelve with myeloradiculopathy and six with radiculopathy. 'Total' configuration of OPLL was the most frequent (70%) [27].
• Radiculopathy as a complication of ankylosing spondylitis [28].

Analytical, diagnostic and therapeutic context of Radiculopathy

• Epidural injection of LTB4 receptor antagonist and/or TXA2 synthetase inhibitor may attenuate the painful radiculopathy due to lumbar disc herniation [29].
• The overlapping coronal-oblique slice MR imaging technique is a reliable and reproducible method for detecting nerve root avulsion [30].
• The C-2 radiculopathy manifested immediately after the patient underwent placement of a ventriculoperitoneal shunt for normal-pressure hydrocephalus [31].
• To analyze by radioimmunoassay the concentration of the neuropeptides substance P and VIP in a model for experimental chronic nerve root compression [32].
• OBJECTIVE: To determine if combining intermittent cervical traction with conventional physical therapy methods is more effective than using conventional approaches alone in the improvement of the grip strength and treatment of the patients with unilateral cervical 7 (C7) radiculopathy [33].

References