Disease relevance of Spinal Stenosis

• We present two cases of nontraumatic cervical myelopathy caused by spinal stenosis at the level of the atlas associated with a hypoplastic but complete posterior arch of C1 [1].
• Imaging revealed a hypoplastic but complete posterior C1 arch associated with changes of spondylosis in both patients, producing severe spinal stenosis and spinal cord compression [1].
• These data show that oral treatment with OP-1206 alpha-CD is effective in improving walking dysfunction induced by spinal canal stenosis, and this therapeutic effect is likely mediated by improved SCBF at the territory of spinal stenosis [2].
• Spinal cord injury, spinal fracture, and spinal stenosis in ankylosing spondylitis [3].
• Symptomatic tandem spinal stenosis (TSS) is characterized by the triad of intermittent neurogenic claudication, progressive gait disturbance, and findings of mixed myelopathy and polyradiculopathy in both the upper and lower extremities [4].

High impact information on Spinal Stenosis

• Pamidronate treatment of the neurologic sequelae of pagetic spinal stenosis [5].
• Rheumatoid arthritis: epidural enhancement as an underestimated cause of subaxial cervical spinal stenosis [6].
• Deposition of calcium pyrophosphate dihydrate within the ligamentum flavum causing either focal or diffuse enlargement can be associated with significant spinal stenosis [7].
• Focal dystonia in spinal stenosis [8].
• Inositol was also significantly reduced in the spinal stenosis group when age matched to controls [9].

Chemical compound and disease context of Spinal Stenosis

• In Control nontreated rats, a significant walking dysfunction was observed from Day 1 after the induction of spinal stenosis and persisted for 14 days when compared with the Sham-Operated group [2].
• Symptoms of spinal stenosis do not improve after epidural steroid injection [10].
• A study of computer-assisted tomography. II. Comparison of metrizamide myelography and computed tomography in the diagnosis of herniated lumbar disc and spinal stenosis [11].
• Enhancement of nerve roots in the lumbosacral spine after intravenous administration of gadolinium contrast agents is seen in benign conditions such as disc herniation and spinal stenosis and may be observed in either the unoperated or postoperative spine [12].
• An orally active prostaglandin E1 analogue, OP-1206 alpha-CD improves walking dysfunction in the rat spinal stenosis model [13].

Anatomical context of Spinal Stenosis

• Computed tomography (CT) scan showed diffuse idiopathic hyperostosis of the posterior vertebral border of C4, C5, C6, and C7 cervical vertebrae, with severe spinal stenosis at C5 and C6 level [14].
• CONCLUSION: Results of this study suggest that Lipo prostaglandin E1 may enhance blood flow in the cauda equina and improve clinical symptoms in some patients with lumbar spinal stenosis [15].

Gene context of Spinal Stenosis

• METHODS: We quantified and localized TIMP expression in ligamentum flavum tissues that had been obtained during surgery from thirty patients with spinal stenosis and from thirty gender-matched control patients with disc herniation [16].
• The concentration of TIMP-2 in the ligamentum flavum was significantly higher in the patients with spinal stenosis (mean, 12.62 ng/mL) than in those with disc herniation (mean, 8.85 ng/mL) (p = 0.028) [16].
• Twelve patients with spinal stenosis and degenerative lumbar spondylolisthesis underwent a laminectomy and partial or complete medial facetectomy as required for decompression of the neural elements, followed by an intertransverse process fusion by placing iliac crest autograft and OP-1 putty between the decorticated transverse processes [17].
• Although central motor conduction time (CMCT) has been used for the diagnosis of lumbosacral spinal stenosis (LSSS), its diagnostic value is limited due to the short length of the involved segment compared to the long length of the total conduction distance [18].
• Each was also identified as having lumbar spinal stenosis without an antecedent history of COPD [19].

Analytical, diagnostic and therapeutic context of Spinal Stenosis

• Metrizamide myelography and epidural venography. Their role in the diagnosis of lumbar disc herniation and spinal stenosis [20].
• METHODS: The concentrations of TGF-beta1 were analyzed in the surgically obtained ligamentum flavum specimens from lumbar spinal stenosis (n = 10; mean age 62.8 years) and disc herniation (n = 10; mean age 35.6 years) by enzyme-linked immunosorbent assay [21].
• This article discusses ankylosing spondylitis and spinal stenosis, including differential features, diagnostic strategy, rehabilitation management, spinal complications of ankylosing spondylitis, and pathophysiology of spinal stenosis [22].
• Twelve patients with spinal stenosis and degenerative lumbar spondylolisthesis underwent laminectomy and partial or complete medial facetectomy as required for decompression of the neural elements followed by intertransverse process fusion by placing iliac crest autograft and OP-1 putty between the decorticated transverse processes [23].
• The purpose of this multi-center clinical pilot study was to evaluate the safety of one such BMP-osteogenic protein 1, in the form of OP-1 putty-combined with autograft for intertransverse process fusion of the lumbar spine in patients with symptomatic spinal stenosis and degenerative spondylolisthesis following spinal decompression [23].

References