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Gene Review

SLM3  -  Slm3p

Saccharomyces cerevisiae S288c

Synonyms: D2761, MTO2, MTU1, Mitochondrial tRNA-specific 2-thiouridylase 1, Mitochondrial translation optimization protein 2, ...
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High impact information on SLM3

  • In addition, we showed that yeast and human Mto2p localize in mitochondria [1].
  • The isolated human MTO2 cDNA can partially restore the respiratory-deficient phenotype of yeast mto2 cells carrying the C1409G mutation [1].
  • Mutations in MTO2 related to tRNA modification impair mitochondrial gene expression and protein synthesis in the presence of a paromomycin resistance mutation in mitochondrial 15 S rRNA [1].
  • Partial inactivation of MTU1 in HeLa cells by small interference RNA also reduced their oxygen consumption and resulted in mitochondria with defective membrane potentials, which are similar phenotypic features observed in MERRF [2].
  • Furthermore, when MTO1 or MSS1, which are responsible for the C5 substituent of the modified uridine, was disrupted along with MTU1, a much more severe reduction in mitochondrial activity was observed [2].

Biological context of SLM3

  • Interestingly, mto2 null mutants expressed a respiratory-deficient phenotype when coexisting with the C1409G mutation of mitochondrial 15 S rRNA at the very conservative site for human deafness-associated 12 S rRNA A1491G and C1409T mutations [1].

Other interactions of SLM3

  • Class 1 includes genes that encode components of the pre-RC and pre-IC and are represented by SLM3, 4 and 5 which are allelic to MCM7, MCM2 and CDC45, respectively [3].


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