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Gene Review

SAM2  -  methionine adenosyltransferase SAM2

Saccharomyces cerevisiae S288c

Synonyms: AdoMet synthase 2, D9719.8, ETH2, MAT 2, Methionine adenosyltransferase 2, ...
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Disease relevance of SAM2

  • In addition a recombinant strain of E. coli has been constructed that expresses the yeast SAM synthetase encoded by the sam2 gene [1].

High impact information on SAM2

  • The activation region contained a repeated dyad sequence that is also found in the promoter regions of other unlinked but coordinately regulated genes (MET3, MET2, and SAM2) [2].
  • The results show that the expression of the two SAM genes is regulated differently, SAM2 being induced by the presence of excess methionine in the growth medium and SAM1 being repressed under the same conditions [3].
  • SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes [3].
  • SAM1 and SAM2, located on chromosomes XII and IV, respectively, encode functionally equivalent although differentially regulated AdoMet synthetases [4].
  • Single frameshift mutations were introduced into the 5' end of SAM1 and the 3' end of SAM2 by restriction site ablation [4].

Biological context of SAM2


Other interactions of SAM2

  • Mutations at the SAM1 locus lead to the absence or to the modification of MATII whereas mutations at the SAM2 locus lead to the absence or to the modification of MATI [7].
  • Clones corresponding to isogenes SAM2 and SAM3 have also been isolated and sequenced [8].


  1. Enzymatic synthesis of S-adenosyl-L-methionine on the preparative scale. Park, J., Tai, J., Roessner, C.A., Scott, A.I. Bioorg. Med. Chem. (1996) [Pubmed]
  2. Elements involved in S-adenosylmethionine-mediated regulation of the Saccharomyces cerevisiae MET25 gene. Thomas, D., Cherest, H., Surdin-Kerjan, Y. Mol. Cell. Biol. (1989) [Pubmed]
  3. SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes. Thomas, D., Rothstein, R., Rosenberg, N., Surdin-Kerjan, Y. Mol. Cell. Biol. (1988) [Pubmed]
  4. A defect in mismatch repair in Saccharomyces cerevisiae stimulates ectopic recombination between homeologous genes by an excision repair dependent process. Bailis, A.M., Rothstein, R. Genetics (1990) [Pubmed]
  5. Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase. Horikawa, S., Ishikawa, M., Ozasa, H., Tsukada, K. Eur. J. Biochem. (1989) [Pubmed]
  6. tRNAs undermethylation in a met-regulatory mutant of Saccharomyces cerevisiae. Fesneau, C., de Robichon-Szulmajster, H., Fradin, A., Feldmann, H. Biochimie (1975) [Pubmed]
  7. S-adenosyl methionine requiring mutants in Saccharomyces cerevisiae: evidences for the existence of two methionine adenosyl transferases. Cherest, H., Surdin-Kerjan, Y. Mol. Gen. Genet. (1978) [Pubmed]
  8. Differential accumulation of S-adenosylmethionine synthetase transcripts in response to salt stress. Espartero, J., Pintor-Toro, J.A., Pardo, J.M. Plant Mol. Biol. (1994) [Pubmed]
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