The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

MAT2A  -  methionine adenosyltransferase II, alpha

Homo sapiens

Synonyms: AMS2, AdoMet synthase 2, MAT 2, MAT-II, MATA2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of MAT2A


High impact information on MAT2A


Biological context of MAT2A

  • Increased trans-activation of these two sites also contributes to MAT2A up-regulation in HCC [5].
  • SAM level and SAM:S-adenosylhomocysteine (SAH) ratio increased by 50-75% after MAT1A transfection and by an additional 60-80% after MAT2A antisense treatment [6].
  • To delineate the molecular basis for the differential regulation of alpha2 subunit expression, we cloned and characterized the human MAT2A gene and its promoter and defined regions that contain enhancer and repressor elements [7].
  • In liver, MAT1A expression is associated with high AdoMet levels and a differentiated phenotype, whereas MAT2A expression is associated with lower AdoMet levels and a dedifferentiated phenotype [8].
  • The region -571 to -270 of the human MAT2A contains a c-Myb consensus binding site. c-Myb is known to be induced during T-lymphocyte activation and its mRNA level was increased after treatment of Jurkat cells with IL-2, PMA or PMA plus PHA [9].

Anatomical context of MAT2A

  • These studies may lead to the delineation of the molecular basis for the differential regulation of MAT2A expression in normal and leukemic T cells [7].
  • In the current work we examined the molecular mechanism of increased MAT2A expression in activated Jurkat cells [9].
  • Dexamethasone, a known inhibitor of lymphocyte activation, blocked the effect of these agents on MAT2A expression by preventing the increase in c-Myb expression [9].

Associations of MAT2A with chemical compounds


Other interactions of MAT2A

  • MAT1A is expressed mostly in the liver, whereas MAT2A is widely distributed [5].
  • At LD, HGF increased the mRNA levels of cyclin A, MAT2A, MAT2beta, and c-met [12].
  • We found that the human MAT2A promoter is hypomethylated in hepatocellular carcinoma, in which the gene is upregulated transcriptionally, but hypermethylated in normal liver, in which the gene is minimally expressed [13].


  1. Methionine adenosyltransferase II beta subunit gene expression provides a proliferative advantage in human hepatoma. Martínez-Chantar, M.L., García-Trevijano, E.R., Latasa, M.U., Martín-Duce, A., Fortes, P., Caballería, J., Avila, M.A., Mato, J.M. Gastroenterology (2003) [Pubmed]
  2. Liver-specific methionine adenosyltransferase MAT1A gene expression is associated with a specific pattern of promoter methylation and histone acetylation: implications for MAT1A silencing during transformation. Torres, L., Avila, M.A., Carretero, M.V., Latasa, M.U., Caballería, J., López-Rodas, G., Boukaba, A., Lu, S.C., Franco, L., Mato, J.M. FASEB J. (2000) [Pubmed]
  3. A cell cycle-regulated GATA factor promotes centromeric localization of CENP-A in fission yeast. Chen, E.S., Saitoh, S., Yanagida, M., Takahashi, K. Mol. Cell (2003) [Pubmed]
  4. The role of c-Myb and Sp1 in the up-regulation of methionine adenosyltransferase 2A gene expression in human hepatocellular carcinoma. Yang, H., Huang, Z.Z., Wang, J., Lu, S.C. FASEB J. (2001) [Pubmed]
  5. Induction of human methionine adenosyltransferase 2A expression by tumor necrosis factor alpha. Role of NF-kappa B and AP-1. Yang, H., Sadda, M.R., Yu, V., Zeng, Y., Lee, T.D., Ou, X., Chen, L., Lu, S.C. J. Biol. Chem. (2003) [Pubmed]
  6. Differential expression of methionine adenosyltransferase genes influences the rate of growth of human hepatocellular carcinoma cells. Cai, J., Mao, Z., Hwang, J.J., Lu, S.C. Cancer Res. (1998) [Pubmed]
  7. Regulation of the human MAT2A gene encoding the catalytic alpha 2 subunit of methionine adenosyltransferase, MAT II: gene organization, promoter characterization, and identification of a site in the proximal promoter that is essential for its activity. Halim, A.B., LeGros, L., Chamberlin, M.E., Geller, A., Kotb, M. J. Biol. Chem. (2001) [Pubmed]
  8. L-methionine availability regulates expression of the methionine adenosyltransferase 2A gene in human hepatocarcinoma cells: role of S-adenosylmethionine. Martínez-Chantar, M.L., Latasa, M.U., Varela-Rey, M., Lu, S.C., García-Trevijano, E.R., Mato, J.M., Avila, M.A. J. Biol. Chem. (2003) [Pubmed]
  9. The role of c-Myb in the up-regulation of methionine adenosyltransferase 2A expression in activated Jurkat cells. Zeng, Z., Yang, H., Huang, Z.Z., Chen, C., Wang, J., Lu, S.C. Biochem. J. (2001) [Pubmed]
  10. Differential effect of thioacetamide on hepatic methionine adenosyltransferase expression in the rat. Huang, Z.Z., Mato, J.M., Kanel, G., Lu, S.C. Hepatology (1999) [Pubmed]
  11. Differential expression of the S-adenosyl-L-methionine synthase genes during pea development. Gómez-Gómez, L., Carrasco, P. Plant Physiol. (1998) [Pubmed]
  12. Effect of hepatocyte growth factor on methionine adenosyltransferase genes and growth is cell density-dependent in HepG2 cells. Yang, H., Magilnick, N., Noureddin, M., Mato, J.M., Lu, S.C. J. Cell. Physiol. (2007) [Pubmed]
  13. Role of promoter methylation in increased methionine adenosyltransferase 2A expression in human liver cancer. Yang, H., Huang, Z.Z., Zeng, Z., Chen, C., Selby, R.R., Lu, S.C. Am. J. Physiol. Gastrointest. Liver Physiol. (2001) [Pubmed]
WikiGenes - Universities