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Gene Review

SAM1  -  methionine adenosyltransferase SAM1

Saccharomyces cerevisiae S288c

Synonyms: AdoMet synthase 1, ETH10, L9470.9, MAT 1, Methionine adenosyltransferase 1, ...
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Disease relevance of SAM1


High impact information on SAM1


Biological context of SAM1

  • Single frameshift mutations were introduced into the 5' end of SAM1 and the 3' end of SAM2 by restriction site ablation [6].
  • SAM1 and SAM2, located on chromosomes XII and IV, respectively, encode functionally equivalent although differentially regulated AdoMet synthetases [6].
  • Null mutations in three recombination and DNA repair genes were studied to determine their effects on mitotic recombination between the duplicate AdoMet (S-adenosylmethionine) synthetase genes (SAM1 and SAM2) in Saccharomyces cerevisiae [6].
  • A study of in vivo and in vitro methylation of tRNAs in regulatory mutants affected in methionine-mediated repression (eth2, eth3, eth10) has led to the following results: 1) The eth2-2 carrying strain presents a great undermethylation of its tRNAs of the same order of magnitude as observed during methionine starvation of methionine auxotrophs [7].
  • In haploid strains, gene sam1 is essential for growth; if weakly expressed, cells mate and sporulate at a reduced rate [8].

Anatomical context of SAM1


Associations of SAM1 with chemical compounds

  • SAM1 and SAM3 mRNAs accumulated in the root in response to NaCl, mannitol or ABA treatments [10].
  • The inhibition of S-adenosylmethionine synthetase by trifluoromethionine prevents both germination and protein synthesis [11].
  • By flow cytometric analysis, a monoclonal antibody (MAb) directed against human alpha 5 integrin subunit (clone SAM-1) and two different antisera to FNr positively stained C. tropicalis, C. stellatoidea and C. glabrata, with the greatest expression observed for C. tropicalis [12].

Other interactions of SAM1


Analytical, diagnostic and therapeutic context of SAM1


  1. Isolation of a cDNA encoding the rat liver S-adenosylmethionine synthetase. Horikawa, S., Ishikawa, M., Ozasa, H., Tsukada, K. Eur. J. Biochem. (1989) [Pubmed]
  2. Genome rearrangement in top3 mutants of Saccharomyces cerevisiae requires a functional RAD1 excision repair gene. Bailis, A.M., Arthur, L., Rothstein, R. Mol. Cell. Biol. (1992) [Pubmed]
  3. SAM2 encodes the second methionine S-adenosyl transferase in Saccharomyces cerevisiae: physiology and regulation of both enzymes. Thomas, D., Rothstein, R., Rosenberg, N., Surdin-Kerjan, Y. Mol. Cell. Biol. (1988) [Pubmed]
  4. SAM1, the structural gene for one of the S-adenosylmethionine synthetases in Saccharomyces cerevisiae. Sequence and expression. Thomas, D., Surdin-Kerjan, Y. J. Biol. Chem. (1987) [Pubmed]
  5. eth-1, the Neurospora crassa locus encoding S-adenosylmethionine synthetase: molecular cloning, sequence analysis and in vivo overexpression. Mautino, M.R., Barra, J.L., Rosa, A.L. Genetics (1996) [Pubmed]
  6. A defect in mismatch repair in Saccharomyces cerevisiae stimulates ectopic recombination between homeologous genes by an excision repair dependent process. Bailis, A.M., Rothstein, R. Genetics (1990) [Pubmed]
  7. tRNAs undermethylation in a met-regulatory mutant of Saccharomyces cerevisiae. Fesneau, C., de Robichon-Szulmajster, H., Fradin, A., Feldmann, H. Biochimie (1975) [Pubmed]
  8. Gene sam1 encoding adenosylmethionine synthetase: effects of its expression in the fission yeast Schizosaccharomyces pombe. Hilti, N., Gräub, R., Jörg, M., Arnold, P., Schweingruber, A.M., Schweingruber, M.E. Yeast (2000) [Pubmed]
  9. Antigenic conservation of primary structural regions of S-adenosylmethionine synthetase. Kotb, M., Geller, A.M., Markham, G.D., Kredich, N.M., De La Rosa, J., Beachey, E.H. Biochim. Biophys. Acta (1990) [Pubmed]
  10. Differential accumulation of S-adenosylmethionine synthetase transcripts in response to salt stress. Espartero, J., Pintor-Toro, J.A., Pardo, J.M. Plant Mol. Biol. (1994) [Pubmed]
  11. Function of S-adenosylmethionine in germinating yeast ascospores. Choih, S.J., Ferro, A.J., Shapiro, S.K. J. Bacteriol. (1977) [Pubmed]
  12. An alpha 5 beta 1-like integrin receptor mediates the binding of less pathogenic Candida species to fibronectin. Santoni, G., Birarelli, P., Hong, L.J., Gamero, A., Djeu, J.Y., Piccoli, M. J. Med. Microbiol. (1995) [Pubmed]
  13. The level of cAMP-dependent protein kinase A activity strongly affects osmotolerance and osmo-instigated gene expression changes in Saccharomyces cerevisiae. Norbeck, J., Blomberg, A. Yeast (2000) [Pubmed]
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