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Gene Review

DGKD  -  diacylglycerol kinase, delta 130kDa

Homo sapiens

Synonyms: 130 kDa diacylglycerol kinase, DAG kinase delta, DGK-delta, DGKdelta, Diacylglycerol kinase delta, ...
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High impact information on DGKD

  • The expression patterns, subcellular distribution, and regulatory mechanisms of DGK kappa are distinct from those of DGKdelta and DGKeta despite high structural similarity, suggesting unique functions of the individual type II isozymes [1].
  • Taken together, alternative splicing of the human DGKdelta gene generates at least two isoforms, differing in their expressions and regulatory functions [2].
  • DGKdelta (type II isozyme) contains a pleckstrin homology domain at the N terminus and a sterile alpha motif domain at the C terminus [2].
  • Interestingly, phorbol ester stimulation induced dissociation of the oligomeric structures with concomitant phosphorylation of DGKdelta [3].
  • In this case, DGKdelta mutants lacking the ability of self-association were localized at the plasma membranes even in the absence of phorbol ester [3].

Biological context of DGKD

  • However, DGK delta lacks the EF-hand motifs (C2) and contains a long Glu- and Ser-rich insertion (317 residues), which divides the C4 region into two portions [4].
  • A fourth member of the diacylglycerol kinase (DGK) gene family termed DGK delta was cloned from the human testis cDNA library [4].

Anatomical context of DGKD


Other interactions of DGKD

  • DGKeta shares substantial homology with DGKdelta including the N-terminal pleckstrin homology domain [6].
  • Taken together, these data are the first to demonstrate an agonist-induced activity of nuclear DGK-theta activity and a nuclear localization of DGK-delta [7].

Analytical, diagnostic and therapeutic context of DGKD


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