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Gene Review

JAC1  -  Jac1p

Saccharomyces cerevisiae S288c

Synonyms: J-type accessory chaperone 1, J-type co-chaperone JAC1, mitochondrial, SEO2, YGL018C
 
 
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High impact information on JAC1

  • Fe/S enzyme activities remain low in both jac1 and ssq1 mutant mitochondria even if normal mitochondrial iron levels are maintained [1].
  • Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae [1].
  • JAC1, an ortholog of hscB, and SSQ1, a paralog of hscA, have been shown to be required for iron-sulfur cluster assembly in mitochondria of Saccharomyces cerevisiae [2].
  • In 56 available genomes we identified two genes with identical phylogenetic distributions to the frataxin/cyaY gene: hscA and hscB/JAC1 [2].
  • Characterization of the interaction between the J-protein Jac1p and the scaffold for Fe-S cluster biogenesis, Isu1p [3].
 

Biological context of JAC1

 

Other interactions of JAC1

  • Taken together these results suggest a role for Ssq1p, Jac1p, and Nfs1p in assembly/maturation of mitochondrial iron-sulfur proteins and that one or more of the target Fe/S proteins contribute to oxidative damage in cells lacking copper/zinc SOD [4].
  • In jac1 mutants, like in ssq1 mutants, processing of the Yfh1p precursor protein from intermediate to mature forms was delayed [5].
  • Taken together, these data suggest that Ssq1p/Jac1p/Mge1p are not important for Fe/S cluster synthesis on Isu1p [6].
  • The mitochondrial DnaJ homolog Jac1 is crucial for this process, whereas Mdj1 function is dispensable [7].

References

  1. Jac1, a mitochondrial J-type chaperone, is involved in the biogenesis of Fe/S clusters in Saccharomyces cerevisiae. Voisine, C., Cheng, Y.C., Ohlson, M., Schilke, B., Hoff, K., Beinert, H., Marszalek, J., Craig, E.A. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  2. The phylogenetic distribution of frataxin indicates a role in iron-sulfur cluster protein assembly. Huynen, M.A., Snel, B., Bork, P., Gibson, T.J. Hum. Mol. Genet. (2001) [Pubmed]
  3. Characterization of the interaction between the J-protein Jac1p and the scaffold for Fe-S cluster biogenesis, Isu1p. Andrew, A.J., Dutkiewicz, R., Knieszner, H., Craig, E.A., Marszalek, J. J. Biol. Chem. (2006) [Pubmed]
  4. Suppressors of superoxide dismutase (SOD1) deficiency in Saccharomyces cerevisiae. Identification of proteins predicted to mediate iron-sulfur cluster assembly. Strain, J., Lorenz, C.R., Bode, J., Garland, S., Smolen, G.A., Ta, D.T., Vickery, L.E., Culotta, V.C. J. Biol. Chem. (1998) [Pubmed]
  5. J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins. Kim, R., Saxena, S., Gordon, D.M., Pain, D., Dancis, A. J. Biol. Chem. (2001) [Pubmed]
  6. The Hsp70 chaperone Ssq1p is dispensable for iron-sulfur cluster formation on the scaffold protein Isu1p. Dutkiewicz, R., Marszalek, J., Schilke, B., Craig, E.A., Lill, R., Mühlenhoff, U. J. Biol. Chem. (2006) [Pubmed]
  7. The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria. Lutz, T., Westermann, B., Neupert, W., Herrmann, J.M. J. Mol. Biol. (2001) [Pubmed]
 
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