Gene Review:
YFH1 - Yfh1p
Saccharomyces cerevisiae S288c
Synonyms:
Frataxin homolog, mitochondrial, YDL120W
- Regulation of mitochondrial iron accumulation by Yfh1p, a putative homolog of frataxin. Babcock, M., de Silva, D., Oaks, R., Davis-Kaplan, S., Jiralerspong, S., Montermini, L., Pandolfo, M., Kaplan, J. Science (1997)
- Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae. Cavadini, P., Gellera, C., Patel, P.I., Isaya, G. Hum. Mol. Genet. (2000)
- A structural approach to understanding the iron-binding properties of phylogenetically different frataxins. Adinolfi, S., Trifuoggi, M., Politou, A.S., Martin, S., Pastore, A. Hum. Mol. Genet. (2002)
- Respiratory deficiency due to loss of mitochondrial DNA in yeast lacking the frataxin homologue. Wilson, R.B., Roof, D.M. Nat. Genet. (1997)
- Inhibition of Fe-S cluster biosynthesis decreases mitochondrial iron export: evidence that Yfh1p affects Fe-S cluster synthesis. Chen, O.S., Hemenway, S., Kaplan, J. Proc. Natl. Acad. Sci. U.S.A. (2002)
- A non-essential function for yeast frataxin in iron-sulfur cluster assembly. Duby, G., Foury, F., Ramazzotti, A., Herrmann, J., Lutz, T. Hum. Mol. Genet. (2002)
- The mitochondrial protein frataxin prevents nuclear damage. Karthikeyan, G., Lewis, L.K., Resnick, M.A. Hum. Mol. Genet. (2002)
- Distinct roles for two N-terminal cleaved domains in mitochondrial import of the yeast frataxin homolog, Yfh1p. Gordon, D.M., Kogan, M., Knight, S.A., Dancis, A., Pain, D. Hum. Mol. Genet. (2001)
- The role of the mitochondrion in cellular iron homeostasis. Schueck, N.D., Woontner, M., Koeller, D.M. Mitochondrion (2001)
- Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron. Mühlenhoff, U., Richhardt, N., Gerber, J., Lill, R. J. Biol. Chem. (2002)
- YFH1-mediated iron homeostasis is independent of mitochondrial respiration. Chen, O.S., Kaplan, J. FEBS Lett. (2001)
- Iron metabolism in mice with partial frataxin deficiency. Santos, M.M., Miranda, C.J., Levy, J.E., Montross, L.K., Cossée, M., Sequeiros, J., Andrews, N., Koenig, M., Pandolfo, M. Cerebellum (2003)
- The yeast frataxin homologue mediates mitochondrial iron efflux. Evidence for a mitochondrial iron cycle. Radisky, D.C., Babcock, M.C., Kaplan, J. J. Biol. Chem. (1999)
- Iron toxicity protection by truncated Ras2 GTPase in yeast strain lacking frataxin. Kucej, M., Foury, F. Biochem. Biophys. Res. Commun. (2003)
- Mitochondrial control of iron homeostasis. A genome wide analysis of gene expression in a yeast frataxin-deficient strain. Foury, F., Talibi, D. J. Biol. Chem. (2001)
- Acidic residues of yeast frataxin have an essential role in Fe-S cluster assembly. Foury, F., Pastore, A., Trincal, M. EMBO Rep. (2007)
- An interaction between frataxin and Isu1/Nfs1 that is crucial for Fe/S cluster synthesis on Isu1. Gerber, J., Mühlenhoff, U., Lill, R. EMBO Rep. (2003)
- Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain. Foury, F., Roganti, T. J. Biol. Chem. (2002)
- Mitochondrial functional interactions between frataxin and Isu1p, the iron-sulfur cluster scaffold protein, in Saccharomyces cerevisiae. Ramazzotti, A., Vanmansart, V., Foury, F. FEBS Lett. (2004)
- J-domain protein, Jac1p, of yeast mitochondria required for iron homeostasis and activity of Fe-S cluster proteins. Kim, R., Saxena, S., Gordon, D.M., Pain, D., Dancis, A. J. Biol. Chem. (2001)
- Biogenesis of the yeast frataxin homolog Yfh1p. Tim44-dependent transfer to mtHsp70 facilitates folding of newly imported proteins in mitochondria. Geissler, A., Krimmer, T., Schönfisch, B., Meijer, M., Rassow, J. Eur. J. Biochem. (2000)