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Gene Review

SER2  -  phosphoserine phosphatase

Saccharomyces cerevisiae S288c

Synonyms: G7744, O-phosphoserine phosphohydrolase, PSP, PSPase, Phosphoserine phosphatase, ...
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Disease relevance of SER2


High impact information on SER2

  • PTPA binding to PP2A results in a dramatic alteration of substrate specificity, with enhanced phosphotyrosine phosphatase activity and decreased phosphoserine phosphatase activity [2].
  • Loss of Paf1 factors causes a reduction of Pol II Ser2 phosphorylation and shortened poly(A) tails, suggesting that the complex facilitates linkage of transcriptional and posttranscriptional events [3].
  • Unlike wild-type cells, cells expressing Ctk1(T338A) delayed growth at early stationary phase, did not show the increase in Ser2 phosphorylation that normally accompanies the transition from rapid growth to stationary phase, and had compromised transcriptional activation of two stationary-phase genes, CTT1 and SPI1 [4].
  • NMR titration shows that the SRI domain binds an Ser2/Ser5-phosphorylated CTD peptide comprising two heptapeptide repeats and three flanking NH2-terminal residues, whereas a single CTD repeat is insufficient for binding [5].
  • Thus, in cells grown on ethanol both expression and activity of all SER-encoded proteins are low, including the remaining enzymes of the phosphoglycerate pathway, Ser1p and Ser2p [6].

Biological context of SER2

  • The PHO81 gene encoding one of the regulators of the phosphatase regulon in Saccharomyces cerevisiae was mapped 9.8 centimorgans distal from the ser2 locus on the right arm of chromosome VII [7].
  • Mutagenesis experiments revealed that yeast eIF-4E activity is not dependent on the presence of Ser2 or Ser15 [8].
  • There appear to be eleven tRNA Ser2 genes in the yeast genome [9].

Associations of SER2 with chemical compounds


  1. Sequencing of a 17.6 kb segment on the right arm of yeast chromosome VII reveals 12 ORFs, including CCT, ADE3 and TR-I genes, homologues of the yeast PMT and EF1G genes, of the human and bacterial electron-transferring flavoproteins (beta-chain) and of the Escherichia coli phosphoserine phosphohydrolase, and five new ORFs. Guerreiro, P., Barreiros, T., Soares, H., Cyrne, L., Maia e Silva, A., Rodrigues-Pousada, C. Yeast (1996) [Pubmed]
  2. Structure and mechanism of the phosphotyrosyl phosphatase activator. Chao, Y., Xing, Y., Chen, Y., Xu, Y., Lin, Z., Li, Z., Jeffrey, P.D., Stock, J.B., Shi, Y. Mol. Cell (2006) [Pubmed]
  3. The Paf1 complex has functions independent of actively transcribing RNA polymerase II. Mueller, C.L., Porter, S.E., Hoffman, M.G., Jaehning, J.A. Mol. Cell (2004) [Pubmed]
  4. Phosphorylation by Cak1 regulates the C-terminal domain kinase Ctk1 in Saccharomyces cerevisiae. Ostapenko, D., Solomon, M.J. Mol. Cell. Biol. (2005) [Pubmed]
  5. Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription. Vojnic, E., Simon, B., Strahl, B.D., Sattler, M., Cramer, P. J. Biol. Chem. (2006) [Pubmed]
  6. Ser3p (Yer081wp) and Ser33p (Yil074cp) are phosphoglycerate dehydrogenases in Saccharomyces cerevisiae. Albers, E., Laizé, V., Blomberg, A., Hohmann, S., Gustafsson, L. J. Biol. Chem. (2003) [Pubmed]
  7. Promoter analysis of the PHO81 gene encoding a 134 kDa protein bearing ankyrin repeats in the phosphatase regulon of Saccharomyces cerevisiae. Ogawa, N., Noguchi, K., Yamashita, Y., Yasuhara, T., Hayashi, N., Yoshida, K., Oshima, Y. Mol. Gen. Genet. (1993) [Pubmed]
  8. Characterization of the in vivo phosphorylation sites of the mRNA.cap-binding complex proteins eukaryotic initiation factor-4E and p20 in Saccharomyces cerevisiae. Zanchin, N.I., McCarthy, J.E. J. Biol. Chem. (1995) [Pubmed]
  9. Characterization of the yeast tRNA Ser genomic organization and DNA sequence. Page, G.S., Hall, B.D. Nucleic Acids Res. (1981) [Pubmed]
  10. Genetic analysis of serine biosynthesis and glucose repression in yeast. Melcher, K., Entian, K.D. Curr. Genet. (1992) [Pubmed]
  11. An encephalitozoon cuniculi ortholog of the RNA polymerase II carboxyl-terminal domain (CTD) serine phosphatase Fcp1. Hausmann, S., Schwer, B., Shuman, S. Biochemistry (2004) [Pubmed]
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