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Gene Review

AMA1  -  Ama1p

Saccharomyces cerevisiae S288c

Synonyms: Activator of meiotic APC/C protein 1, G8541, Meiosis-specific APC/C activator protein AMA1, SPO70, Sporulation-specific protein 70, ...
 
 
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High impact information on AMA1

  • The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1 [1].
  • The meiosis-specific processing of AMA1 mRNA depends on the previously described MER1 splicing factor [2].
  • Third, ectopic overexpression of AMA1 is able to stimulate ubiquitination of Clb1p in vitro and degradation of Clb1p in vivo [2].
  • Mutants lacking AMA1 revealed that it is required for the first meiotic division but not the mitotic-like meiosis II [2].
  • Here we describe the yeast gene AMA1, a new member of the Cdc20 protein family that regulates the multisubunit ubiquitin ligase termed the anaphase promoting complex/cyclosome (APC/C) [2].
 

Biological context of AMA1

  • The requirement of Ama1p only for meiosis I and spore morphogenesis suggests a function for APC/C(Ama1) specifically adapted to germ cell development [2].
  • In conclusion, this study indicates that Ama1p directs a meiotic APC/C that functions solely outside mitotic cell division [2].
  • During S- and prophase, Mnd2 prevents activation of the APC/C by a meiosis-specific activator called Ama1 [1].
  • The function of Ama1 in regulating Smk1 is independent of the FEAR network, which promotes exit from mitosis and exit from meiosis I through the Cdc14 phosphatase [3].
  • To prevent nonnative glycosylation, a conservatively mutagenized PV66/AMA-1 gene (PV66Deltaglyc) lacking N-glycosylation sites was also developed [4].
 

Regulatory relationships of AMA1

  • The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast [3].
 

Other interactions of AMA1

  • Second, Ama1p is required for the degradation of the B-type cyclin Clb1p, an APC/C substrate in both meiotic and mitotic cells [2].
  • The data indicate that Cdc28 and Ama1 function in a pathway to trigger Smk1-dependent steps in spore morphogenesis [3].
  • Here we show that Ama1, a meiosis-specific activator of the anaphase-promoting complex/cyclosome (APC/C), promotes Smk1 activation during meiosis [3].

References

  1. The yeast APC/C subunit Mnd2 prevents premature sister chromatid separation triggered by the meiosis-specific APC/C-Ama1. Oelschlaegel, T., Schwickart, M., Matos, J., Bogdanova, A., Camasses, A., Havlis, J., Shevchenko, A., Zachariae, W. Cell (2005) [Pubmed]
  2. Ama1p is a meiosis-specific regulator of the anaphase promoting complex/cyclosome in yeast. Cooper, K.F., Mallory, M.J., Egeland, D.B., Jarnik, M., Strich, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. The Ama1-directed anaphase-promoting complex regulates the Smk1 mitogen-activated protein kinase during meiosis in yeast. McDonald, C.M., Cooper, K.F., Winter, E. Genetics (2005) [Pubmed]
  4. High-level expression of Plasmodium vivax apical membrane antigen 1 (AMA-1) in Pichia pastoris: strong immunogenicity in Macaca mulatta immunized with P. vivax AMA-1 and adjuvant SBAS2. Kocken, C.H., Dubbeld, M.A., Van Der Wel, A., Pronk, J.T., Waters, A.P., Langermans, J.A., Thomas, A.W. Infect. Immun. (1999) [Pubmed]
 
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