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Gene Review

PRS1  -  ribose phosphate diphosphokinase subunit PRS1

Saccharomyces cerevisiae S288c

Synonyms: PPS1, PRP1, PRPS, PRPS1, Phosphoribosyl pyrophosphate synthase 1, ...
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High impact information on PRS1


Biological context of PRS1

  • The Saccharomyces cerevisiae genome contains a family of five PRS genes, PRS1-PRS5 [5].
  • Heterozygotes in PRS1 produced approximately 35% less PRPP synthetase (P = 0.0004) and exhibited a similar reduction in transcript levels [6].
  • While no role in morphogenesis is elucidated by this work, the data strongly suggests that PRS1 is an essential gene in C. albicans and supports earlier results that indicated the presence of a single PRS gene in C. albicans [6].

Anatomical context of PRS1


Other interactions of PRS1

  • A FASTA search indicated that the C. albicans PRS (Ca PRS1) had an overall homology at the amino acid level of 91% with the S. cerevisiae PRS3 [7].

Analytical, diagnostic and therapeutic context of PRS1

  • Confirmation of a heterozygous, single disruption in PRS1 was obtained by I-SceI digestion of chromosomal-sized DNA and Southern blot hybridizations [6].


  1. The Saccharomyces cerevisiae mutation elm4-1 facilitates pseudohyphal differentiation and interacts with a deficiency in phosphoribosylpyrophosphate synthase activity to cause constitutive pseudohyphal growth. Blacketer, M.J., Madaule, P., Myers, A.M. Mol. Cell. Biol. (1994) [Pubmed]
  2. Heterooligomeric phosphoribosyl diphosphate synthase of Saccharomyces cerevisiae: combinatorial expression of the five PRS genes in Escherichia coli. Hove-Jensen, B. J. Biol. Chem. (2004) [Pubmed]
  3. The prp1+ gene required for pre-mRNA splicing in Schizosaccharomyces pombe encodes a protein that contains TPR motifs and is similar to Prp6p of budding yeast. Urushiyama, S., Tani, T., Ohshima, Y. Genetics (1997) [Pubmed]
  4. Characterization of the promoter of PRS1 in Saccharomyces cerevisiae identifies three regions potentially involved in control of expression. Hernando, Y., Carter, A.T., Sickinger, S., Schweizer, M. J. Bacteriol. (2001) [Pubmed]
  5. The importance of the five phosphoribosyl-pyrophosphate synthetase (Prs) gene products of Saccharomyces cerevisiae in the maintenance of cell integrity and the subcellular localization of Prs1p. Schneiter, R., Carter, A.T., Hernando, Y., Zellnig, G., Schweizer, L.M., Schweizer, M. Microbiology (Reading, Engl.) (2000) [Pubmed]
  6. Characterization of the phosphoribosylpyrophosphate synthetase gene from Candida albicans. Payne, T., Calderone, R. J. Med. Vet. Mycol. (1997) [Pubmed]
  7. Isolation of phosphoribosylpyrophosphate synthetase (PRS1) gene from Candida albicans. Payne, T.L., Calderone, R.A. Yeast (1995) [Pubmed]
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