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Gene Review

MIF2  -  Mif2p

Saccharomyces cerevisiae S288c

Synonyms: Protein MIF2, YKL089W
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High impact information on MIF2


Biological context of MIF2

  • Here we provide genetic evidence that MIF2 encodes a centromere protein [4].
  • Specifically, we found that mutations in MIF2 stabilize dicentric minichromosomes and confer high instability (i.e., a synthetic acentric phenotype) to chromosomes that bear a cis-acting mutation in element I of the yeast centromeric DNA (CDEI) [4].
  • The MIF2 gene of Saccharomyces cerevisiae has been implicated in mitosis [4].
  • The Mif2 and Cep1 proteins contain motifs of known transcription factors, suggesting that assembly of the yeast centromere is analogous to that of eukaryotic enhancers and origins of replication [4].
  • When MIF2 was overexpressed, chromosomes missegregated during mitosis and cells accumulated in the G2 and M phases of the cell cycle [5].

Anatomical context of MIF2

  • Studies using temperature-sensitive mutants showed that the loss of yeast Mif2 protein function results in chromosome missegregation, mitotic delay, and aberrant microtubule morphologies (2) [6].

Physical interactions of MIF2

  • Taken together, these data suggest that the Mif2 protein interacts with Cep1p at the centromere and that the yeast centromere indeed exists as a higher order protein-DNA complex [4].

Other interactions of MIF2


  1. Isolation of two genes that affect mitotic chromosome transmission in S. cerevisiae. Meeks-Wagner, D., Wood, J.S., Garvik, B., Hartwell, L.H. Cell (1986) [Pubmed]
  2. Budding yeast centromere composition and assembly as revealed by in vivo cross-linking. Meluh, P.B., Koshland, D. Genes Dev. (1997) [Pubmed]
  3. Architecture of the budding yeast kinetochore reveals a conserved molecular core. Westermann, S., Cheeseman, I.M., Anderson, S., Yates, J.R., Drubin, D.G., Barnes, G. J. Cell Biol. (2003) [Pubmed]
  4. Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. Meluh, P.B., Koshland, D. Mol. Biol. Cell (1995) [Pubmed]
  5. MIF2 is required for mitotic spindle integrity during anaphase spindle elongation in Saccharomyces cerevisiae. Brown, M.T., Goetsch, L., Hartwell, L.H. J. Cell Biol. (1993) [Pubmed]
  6. Characterization of mouse ubiquitin-like SMT3A and SMT3B cDNAs and gene/pseudogenes. Chen, A., Mannen, H., Li, S.S. Biochem. Mol. Biol. Int. (1998) [Pubmed]
  7. Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein gene. Mannen, H., Tseng, H.M., Cho, C.L., Li, S.S. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
  8. The sequence of a 17.5 kb DNA fragment on the left arm of yeast chromosome XI identifies the protein kinase gene ELM1, the DNA primase gene PRI2, a new gene encoding a putative histone and seven new open reading frames. Purnelle, B., Tettelin, H., Van Dyck, L., Skala, J., Goffeau, A. Yeast (1993) [Pubmed]
  9. PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia. Boddy, M.N., Howe, K., Etkin, L.D., Solomon, E., Freemont, P.S. Oncogene (1996) [Pubmed]
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