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Gene Review

YNK1  -  nucleoside diphosphate kinase

Saccharomyces cerevisiae S288c

Synonyms: NDK, NDK1, NDP kinase, Nucleoside diphosphate kinase, YKL067W, ...
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High impact information on YNK1

  • Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry [1].
  • C5 among the beta-type subunits and C8 among the alpha-type subunits were autophosphorylated during the gamma-phosphate transfer reaction and were photoaffinity labeled with 8-azido-[alpha-(32)P]ATP, suggesting that the C5 and C8 subunits of the proteasome are responsible for the NDP kinase-like activity [2].
  • Disruption of ndk1 greatly reduced the cellular NDK activity but caused no obvious phenotype in cell growth and sexual development of the organism [3].
  • This allele carried a point mutation in cysteine 116, which locates next to the putative active center histidine 117, and the mutant gene product showed no NDK activity [3].
  • A mechanism for this partitioning is suggested by our observations that interaction with a 40 kDa protein of the translocase of outer mitochondrial membrane (Tom40p), occurs preferentially with unfolded, unphosphorylated forms of Ynk1p [4].

Biological context of YNK1


Anatomical context of YNK1

  • A population of newly translated, but not yet folded or autophosphorylated, Ynk1p intermediates may be imported into the IMS of mitochondria and trapped there by subsequent folding and oligomerization [4].
  • In rat liver mitochondria all nucleoside diphosphate kinase of the outer compartment is associated with the outer surface of the outer membrane (Lipskaya, T. Yu., and Plakida, K. N. (2003) Biochemistry (Moscow), 68, 1136-1144) [9].

Associations of YNK1 with chemical compounds


Other interactions of YNK1


Analytical, diagnostic and therapeutic context of YNK1


  1. Binding of nucleotides to guanylate kinase, p21(ras), and nucleoside-diphosphate kinase studied by nano-electrospray mass spectrometry. Prinz, H., Lavie, A., Scheidig, A.J., Spangenberg, O., Konrad, M. J. Biol. Chem. (1999) [Pubmed]
  2. Intrinsic nucleoside diphosphate kinase-like activity is a novel function of the 20 S proteasome. Yano, M., Mori, S., Kido, H. J. Biol. Chem. (1999) [Pubmed]
  3. Cloning and functional analysis of the ndk1 gene encoding nucleoside-diphosphate kinase in Schizosaccharomyces pombe. Izumiya, H., Yamamoto, M. J. Biol. Chem. (1995) [Pubmed]
  4. Nucleoside diphosphate kinase of Saccharomyces cerevisiae, Ynk1p: localization to the mitochondrial intermembrane space. Amutha, B., Pain, D. Biochem. J. (2003) [Pubmed]
  5. Temporal and spatial distributions of yeast nucleoside diphosphate kinase activities and its association with the Cdc8p. Zhang, S.Q., Hu, Y., Jong, A.Y. Cell. Mol. Biol. Res. (1995) [Pubmed]
  6. Isolation, overexpression and disruption of a Saccharomyces cerevisiae YNK gene encoding nucleoside diphosphate kinase. Fukuchi, T., Nikawa, J., Kimura, N., Watanabe, K. Gene (1993) [Pubmed]
  7. Saccharomyces cerevisiae nucleoside-diphosphate kinase: purification, characterization, and substrate specificity. Jong, A.Y., Ma, J.J. Arch. Biochem. Biophys. (1991) [Pubmed]
  8. Sequence of a 20.7 kb region of yeast chromosome XI includes the NUP100 gene, an open reading frame (ORF) possibly representing a nucleoside diphosphate kinase gene, tRNAs for His, Val and Trp in addition to seven ORFs with weak or no significant similarity to known proteins. Rasmussen, S.W. Yeast (1994) [Pubmed]
  9. Functional coupling between nucleoside diphosphate kinase of the outer mitochondrial compartment and oxidative phosphorylation. Lipskaya, T.Y., Voinova, V.V. Biochemistry Mosc. (2005) [Pubmed]
  10. Potential roles of 3'-5' exonuclease activity of NM23-H1 in DNA repair and malignant progression. Kaetzel, D.M., Zhang, Q., Yang, M., McCorkle, J.R., Ma, D., Craven, R.J. J. Bioenerg. Biomembr. (2006) [Pubmed]
  11. Anabolism of amdoxovir: phosphorylation of dioxolane guanosine and its 5'-phosphates by mammalian phosphotransferases. Feng, J.Y., Parker, W.B., Krajewski, M.L., Deville-Bonne, D., Veron, M., Krishnan, P., Cheng, Y.C., Borroto-Esoda, K. Biochem. Pharmacol. (2004) [Pubmed]
  12. Cyclic AMP affinity purification and ESI-QTOF MS-MS identification of cytosolic glyceraldehyde 3-phosphate dehydrogenase and two nucleoside diphosphate kinase isoforms from tobacco BY-2 cells. Laukens, K., Roef, L., Witters, E., Slegers, H., Van Onckelen, H. FEBS Lett. (2001) [Pubmed]
  13. Real-time bioluminometric method for detection of nucleoside diphosphate kinase activity. Karamohamed, S., Nordström, T., Nyrén, P. BioTechniques (1999) [Pubmed]
  14. Interactions of phocein with nucleoside-diphosphate kinase, Eps15, and Dynamin I. Baillat, G., Gaillard, S., Castets, F., Monneron, A. J. Biol. Chem. (2002) [Pubmed]
  15. Interaction of nucleoside diphosphate kinase and catalases for stress and light responses in Neurospora crassa. Yoshida, Y., Ogura, Y., Hasunuma, K. FEBS Lett. (2006) [Pubmed]
  16. Isolation of the myc transcription factor nucleoside diphosphate kinase and the multifunctional enzyme glyceraldehyde-3-phosphate dehydrogenase by cAMP affinity chromatography. Weber, B., Weber, W., Buck, F., Hilz, H. Int. J. Biochem. Cell Biol. (1995) [Pubmed]
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