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Gene Review

SFL1  -  Sfl1p

Saccharomyces cerevisiae S288c

Synonyms: Flocculation suppression protein, Protein SFL1, YOR140W, YOR3339W
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High impact information on SFL1

  • Moreover, LexA-Sfl1 represses transcription of a reporter, and repression is reduced in an srb9 mutant [1].
  • Sfl1 acts on SUC2 through a repression site located immediately 5' to the TATA box, and Sfl1 binds this DNA sequence in vitro [1].
  • NRG1 and SFL1 expression requires the Srb8-11 complex, and correspondingly, the Srb8-11 complex is also necessary for STA1 repression [2].
  • Here we demonstrate that glucose-dependent repression of STA1 expression is imposed by both Sfl1 and Nrg1, which serve as direct transcriptional repressors [2].
  • In addition, we show that the levels of Nrg1 and Sfl1 increase in glucose-grown cells, suggesting that the effects of glucose are mediated, at least in part, through an increase in the abundance of these repressors [2].

Biological context of SFL1

  • An active ribozyme sequence, targeted for the SFL1 gene (a yeast suppressor gene for flocculation) was fused just downstream of the T7 promoter [3].
  • These data indicate a possible mechanism for regulating Sfl1-mediated repression through modulation of DNA binding by cAMP-dependent protein kinase-dependent phosphorylation [4].

Physical interactions of SFL1

  • In addition, the N-terminal region of the SFL1 gene product shows extensive homology to the DNA-binding domain of HSTF [5].
  • Sfl1 is known to interact with Tpk2, a cAMP-dependent protein kinase that negatively regulates Sfl1 function [4].

Other interactions of SFL1


Analytical, diagnostic and therapeutic context of SFL1


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