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Gene Review

RPS28A  -  ribosomal 40S subunit protein S28A

Saccharomyces cerevisiae S288c

Synonyms: 40S ribosomal protein S28-A, O3600, RPS33, RPS33A, S33, ...
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Disease relevance of RPS28A

  • E. coli ribosomal proteins L5, L11, L20, S2, S3 and S15/S16 were found to overlap with L15, L11/L16, L36/L37, S3, S10 and S33 from S. cerevisiae, respectively [1].

High impact information on RPS28A

  • RPS28A maps to the right arm of chromosome VII and RPS28B to the right arm of chromosome XVI [2].
  • Strong binding sites for GFI are present in the upstream activating sequences of the gene encoding the 40 kDa subunit II of the QH2:cytochrome c reductase, the gene encoding ribosomal protein S33 and in the intron of the actin gene [3].
  • Taking these findings into account, we present a model for the carbon-source dependent transcription activation of the gene encoding S33 [4].
  • The extended promoter of the gene encoding ribosomal protein S33 in yeast consists of multiple protein binding elements [4].
  • It binds a trans-acting factor designated SUF (S33 Upstream Factor) [4].

Biological context of RPS28A


Physical interactions of RPS28A

  • An ABF1-binding site is present in the upstream region of the S33 gene of K. marxianus [8].

Regulatory relationships of RPS28A


Other interactions of RPS28A

  • One of these, encoded by RPS28A and RPS28B (RPS28), is comparable to bacterial S12 [9].
  • Some other rp-genes (e.g. those encoding S33 and L45) do not contain an RPG-box [10].
  • Nitrogen induction of RPL1, RPL25 and RPS33 was much less dependent on the presence of the sugar, and only phosphorylated sugar caused a further increase in expression [11].


  1. Comparative study between prokaryotes and eukaryotes by chemical iodination of ribosomal proteins. Bernabeu, C., Vázquez, D., Conde, F.P. Biochim. Biophys. Acta (1979) [Pubmed]
  2. A novel cloning strategy reveals the gene for the yeast homologue to Escherichia coli ribosomal protein S12. Alksne, L.E., Warner, J.R. J. Biol. Chem. (1993) [Pubmed]
  3. Yeast general transcription factor GFI: sequence requirements for binding to DNA and evolutionary conservation. Dorsman, J.C., van Heeswijk, W.C., Grivell, L.A. Nucleic Acids Res. (1990) [Pubmed]
  4. The extended promoter of the gene encoding ribosomal protein S33 in yeast consists of multiple protein binding elements. Herruer, M.H., Mager, W.H., Doorenbosch, T.M., Wessels, P.L., Wassenaar, T.M., Planta, R.J. Nucleic Acids Res. (1989) [Pubmed]
  5. Different roles for abf1p and a T-rich promoter element in nucleosome organization of the yeast RPS28A gene. Lascaris, R.F., Groot, E., Hoen, P.B., Mager, W.H., Planta, R.J. Nucleic Acids Res. (2000) [Pubmed]
  6. Mutations in yeast ribosomal proteins S28 and S4 affect the accuracy of translation and alter the sensitivity of the ribosomes to paromomycin. Synetos, D., Frantziou, C.P., Alksne, L.E. Biochim. Biophys. Acta (1996) [Pubmed]
  7. Yeast ribosomal protein S33 is encoded by an unsplit gene. Leer, R.J., van Raamsdonk-Duin, M.M., Schoppink, P.J., Cornelissen, M.T., Cohen, L.H., Mager, W.H., Planta, R.J. Nucleic Acids Res. (1983) [Pubmed]
  8. Structure and expression of the ABF1-regulated ribosomal protein S33 gene in Kluyveromyces. Hoekstra, R., Ferreira, P.M., Bootsman, T.C., Mager, W.H., Planta, R.J. Yeast (1992) [Pubmed]
  9. Alterations in ribosomal protein RPS28 can diversely affect translational accuracy in Saccharomyces cerevisiae. Anthony, R.A., Liebman, S.W. Genetics (1995) [Pubmed]
  10. Coordinate expression of ribosomal protein genes in yeast as a function of cellular growth rate. Mager, W.H., Planta, R.J. Mol. Cell. Biochem. (1991) [Pubmed]
  11. Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources. Pernambuco, M.B., Winderickx, J., Crauwels, M., Griffioen, G., Mager, W.H., Thevelein, J.M. Microbiology (Reading, Engl.) (1996) [Pubmed]
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