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Gene Review

COT1  -  metal cation transporter COT1

Saccharomyces cerevisiae S288c

Synonyms: Cobalt uptake protein COT1, O6131, YOR316C
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Disease relevance of COT1


High impact information on COT1

  • We also show that the vacuolar CDF proteins Zrc1 and Cot1 are other pathways of ER zinc acquisition [2].
  • The COT1 gene of Saccharomyces cerevisiae has been isolated as a dosage-dependent suppressor of cobalt toxicity [3].
  • Overexpression of the COT1 gene confers increased tolerance to cobalt and rhodium ions but not other divalent cations [3].
  • The increased tolerance of strains containing multiple copies of the COT1 gene is probably due to increased compartmentalization or sequestration of the ion within mitochondria [3].
  • The COT1 protein shares 60% identity with the ZRC1 gene product, which confers resistance to zinc and cadmium ions [3].

Biological context of COT1


Anatomical context of COT1

  • Zinc-replete cells accumulate zinc in the vacuole via the Zrc1p and Cot1p transporters [5].


  1. Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae. Conklin, D.S., Culbertson, M.R., Kung, C. Mol. Gen. Genet. (1994) [Pubmed]
  2. Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function. Ellis, C.D., Wang, F., MacDiarmid, C.W., Clark, S., Lyons, T., Eide, D.J. J. Cell Biol. (2004) [Pubmed]
  3. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Conklin, D.S., McMaster, J.A., Culbertson, M.R., Kung, C. Mol. Cell. Biol. (1992) [Pubmed]
  4. The Neurospora crassa colonial temperature-sensitive 3 (cot-3) gene encodes protein elongation factor 2. Propheta, O., Vierula, J., Toporowski, P., Gorovits, R., Yarden, O. Mol. Gen. Genet. (2001) [Pubmed]
  5. Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. MacDiarmid, C.W., Gaither, L.A., Eide, D. EMBO J. (2000) [Pubmed]
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