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Gene Review

ZRC1  -  Zn(2+) transporter ZRC1

Saccharomyces cerevisiae S288c

Synonyms: YM9408.05C, YMR243C, Zinc/cadmium resistance protein
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Disease relevance of ZRC1


High impact information on ZRC1

  • We also show that the vacuolar CDF proteins Zrc1 and Cot1 are other pathways of ER zinc acquisition [3].
  • Surprisingly, transcription of ZRC1 is induced in zinc-limited cells by the zinc-responsive transcription factor Zap1 [4].
  • We show here that this increase in ZRC1 expression is a novel mechanism of zinc homeostasis and stress tolerance [4].
  • Experiments using the zinc-responsive fluorophore FuraZin-1 as an indicator of vacuolar zinc levels indicated that Zrc1 is required for the rapid transport of zinc into the vacuole during zinc shock [4].
  • Both Zrc1-dependent and independent activities showed a high specificity for Zn(2+) over other physiologically relevant substrates such as Ca2+, Fe2+, and Mn2+ [5].

Biological context of ZRC1


Anatomical context of ZRC1


Associations of ZRC1 with chemical compounds

  • The COT1 protein shares 60% identity with the ZRC1 gene product, which confers resistance to zinc and cadmium ions [8].

Other interactions of ZRC1

  • Multiple copies of transition metal transporter resistance genes, such as COT1 or ZRC1, do not reduce the metal sensitivity of fet3 mutations [9].


  1. Interactions between gene products involved in divalent cation transport in Saccharomyces cerevisiae. Conklin, D.S., Culbertson, M.R., Kung, C. Mol. Gen. Genet. (1994) [Pubmed]
  2. Two genes encoding Arabidopsis halleri MTP1 metal transport proteins co-segregate with zinc tolerance and account for high MTP1 transcript levels. Dräger, D.B., Desbrosses-Fonrouge, A.G., Krach, C., Chardonnens, A.N., Meyer, R.C., Saumitou-Laprade, P., Krämer, U. Plant J. (2004) [Pubmed]
  3. Zinc and the Msc2 zinc transporter protein are required for endoplasmic reticulum function. Ellis, C.D., Wang, F., MacDiarmid, C.W., Clark, S., Lyons, T., Eide, D.J. J. Cell Biol. (2004) [Pubmed]
  4. Induction of the ZRC1 metal tolerance gene in zinc-limited yeast confers resistance to zinc shock. MacDiarmid, C.W., Milanick, M.A., Eide, D.J. J. Biol. Chem. (2003) [Pubmed]
  5. Biochemical properties of vacuolar zinc transport systems of Saccharomyces cerevisiae. MacDiarmid, C.W., Milanick, M.A., Eide, D.J. J. Biol. Chem. (2002) [Pubmed]
  6. Zinc transporters that regulate vacuolar zinc storage in Saccharomyces cerevisiae. MacDiarmid, C.W., Gaither, L.A., Eide, D. EMBO J. (2000) [Pubmed]
  7. The Zrc1 is involved in zinc transport system between vacuole and cytosol in Saccharomyces cerevisiae. Miyabe, S., Izawa, S., Inoue, Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  8. COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Conklin, D.S., McMaster, J.A., Culbertson, M.R., Kung, C. Mol. Cell. Biol. (1992) [Pubmed]
  9. Defects in the yeast high affinity iron transport system result in increased metal sensitivity because of the increased expression of transporters with a broad transition metal specificity. Li, L., Kaplan, J. J. Biol. Chem. (1998) [Pubmed]
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