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Gene Review

PLB2  -  Plb2p

Saccharomyces cerevisiae S288c

Synonyms: Lysophospholipase 2, Phospholipase B 2, YM8270.08C, YMR006C
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Disease relevance of PLB2


High impact information on PLB2


Biological context of PLB2

  • PLB2 gene expression was found to be maximal during exponential growth conditions and was decreased in late phase, in a manner similar to other genes involved in phospholipid metabolism [3].

Anatomical context of PLB2


Associations of PLB2 with chemical compounds

  • Similar to Plb1p, Plb2p appears to accept all major phospholipid classes, with a preference for acidic phospholipids including phosphatidylinositol 3',4'-bisphosphate and phosphatidic acid [2].
  • At the pH optimum of 2.5-3.5, the order of substrate preference of Plb1p and Plb2p is PtdSer (phosphatidylserine)>PtdIns>PtdCho (phosphatidylcholine>PtdEtn (phosphatidylethanolamine) [4].
  • This effect is ascribed to the pH response of Plb1p, because Plb2p does not contribute to the degradation of PtdIns and PtdCho in vivo [4].


  1. Phospholipase B from the plasma membrane of Saccharomyces cerevisiae. Separation of two forms with different carbohydrate content. Witt, W., Schweingruber, M.E., Mertsching, A. Biochim. Biophys. Acta (1984) [Pubmed]
  2. Characterization and function in vivo of two novel phospholipases B/lysophospholipases from Saccharomyces cerevisiae. Merkel, O., Fido, M., Mayr, J.A., Prüger, H., Raab, F., Zandonella, G., Kohlwein, S.D., Paltauf, F. J. Biol. Chem. (1999) [Pubmed]
  3. The PLB2 gene of Saccharomyces cerevisiae confers resistance to lysophosphatidylcholine and encodes a phospholipase B/lysophospholipase. Fyrst, H., Oskouian, B., Kuypers, F.A., Saba, J.D. Biochemistry (1999) [Pubmed]
  4. Regulation of activity in vitro and in vivo of three phospholipases B from Saccharomyces cerevisiae. Merkel, O., Oskolkova, O.V., Raab, F., El-Toukhy, R., Paltauf, F. Biochem. J. (2005) [Pubmed]
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