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Gene Review

YEATS4  -  YEATS domain containing 4

Homo sapiens

Synonyms: 4930573H17Rik, B230215M10Rik, GAS41, Gas41, Glioma-amplified sequence 41, ...
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Disease relevance of YEATS4


High impact information on YEATS4


Biological context of YEATS4


Anatomical context of YEATS4


Physical interactions of YEATS4


Other interactions of YEATS4

  • However, during evolution, the TACC proteins have now acquired the ability to directly interact with components of these complexes (such as the LSm proteins, nuclear hormone receptors, GAS41, and transcription factors) [8].

Analytical, diagnostic and therapeutic context of YEATS4


  1. Expression, cellular distribution and protein binding of the glioma amplified sequence (GAS41), a highly conserved putative transcription factor. Munnia, A., Schütz, N., Romeike, B.F., Maldener, E., Glass, B., Maas, R., Nastainczyk, W., Feiden, W., Fischer, U., Meese, E. Oncogene (2001) [Pubmed]
  2. GAS41 is required for repression of the p53 tumor suppressor pathway during normal cellular proliferation. Park, J.H., Roeder, R.G. Mol. Cell. Biol. (2006) [Pubmed]
  3. The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. Debernardi, S., Bassini, A., Jones, L.K., Chaplin, T., Linder, B., de Bruijn, D.R., Meese, E., Young, B.D. Blood (2002) [Pubmed]
  4. Cloning of a novel transcription factor-like gene amplified in human glioma including astrocytoma grade I. Fischer, U., Heckel, D., Michel, A., Janka, M., Hulsebos, T., Meese, E. Hum. Mol. Genet. (1997) [Pubmed]
  5. Targeted disruption of the GAS41 gene encoding a putative transcription factor indicates that GAS41 is essential for cell viability. Zimmermann, K., Ahrens, K., Matthes, S., Buerstedde, J.M., Strätling, W.H., Phi-van, L. J. Biol. Chem. (2002) [Pubmed]
  6. Multiple mechanisms regulate NuMA dynamics at spindle poles. Kisurina-Evgenieva, O., Mack, G., Du, Q., Macara, I., Khodjakov, A., Compton, D.A. J. Cell. Sci. (2004) [Pubmed]
  7. Molecular cloning, genomic structure and interactions of the putative breast tumor suppressor TACC2. Lauffart, B., Gangisetty, O., Still, I.H. Genomics (2003) [Pubmed]
  8. Structure-function evolution of the transforming acidic coiled coil genes revealed by analysis of phylogenetically diverse organisms. Still, I.H., Vettaikkorumakankauv, A.K., DiMatteo, A., Liang, P. BMC Evol. Biol. (2004) [Pubmed]
  9. GAS41, a highly conserved protein in eukaryotic nuclei, binds to NuMA. Harborth, J., Weber, K., Osborn, M. J. Biol. Chem. (2000) [Pubmed]
  10. GAS41 interacts with transcription factor AP-2beta and stimulates AP-2beta-mediated transactivation. Ding, X., Fan, C., Zhou, J., Zhong, Y., Liu, R., Ren, K., Hu, X., Luo, C., Xiao, S., Wang, Y., Feng, D., Zhang, J. Nucleic Acids Res. (2006) [Pubmed]
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