Disease relevance of cesium

• Synchrotron radiation diffraction data for phage T2 CsDNA fibres have been used to determine the co-ordinates of the caesium ions in crystalline B form DNA [1].
• 6. Addition of caesium ions produced bradycardia with membrane potential changes similar to those seen during vagal stimulation [2].
• The results of sustained caesium administration were compared to those of bolus dose caesium and found to be similar in terms of changes in metabolic, electrophysiological, and haemodynamic variables, and the nature of resulting ventricular arrhythmias [3].
• Caesium administration by either method consistently induced ventricular tachyarrhythmias that were either monoform or polymorphic, rarely had the morphological features of Torsades de Pointes, and frequently degenerated to ventricular fibrillation [3].
• Cardiovascular and metabolic effects of caesium chloride injection in dogs--limitations as a model for the long QT syndrome [3].

Psychiatry related information on cesium

• Caesium levels in manic depressive psychosis [4].
• Information on caesium retention in lynx and better estimates of deposition densities in lynxes' home ranges are important for further elucidation of factors influencing (137)Cs contamination in lynxes [5].
• It can therefore not yet be decided whether the changes in the blood caesium levels in the patients are due to a decrease in renal excretion or are only a secondary effect of unnoticed changes in dietary habits [6].

High impact information on cesium

• The effect of an infusion of natural motilin on the rate of gastric emptying of a standard breakfast was studied in 5 subjects using Caesium 129-tagged resin particles [7].
• 6. SDS-PAGE and silver staining of lysates of SCV and LCV purified by caesium chloride-equilibrium density centrifugation revealed a number of proteins unique to each cell type [8].
• In yeast cells, of which the intracellular potassium had been partly replaced by rubidium or caesium, the intracellular ion distribution was studied by means of energy-dispersive X-ray microanalysis [9].
• The locations and numbers of potassium binding sites also differ considerably from the locations and numbers of caesium binding sites in the other structure [10].
• Csi52, a caesium-insensitive mutant of Arabidopsis thaliana which is defective in potassium transport, is further characterized here using conventional electrophysiology, patch-clamp and radiometric approaches to identify the nature of the potassium transport lesion [11].

Chemical compound and disease context of cesium

• Nicorandil suppresses early afterdepolarisation and ventricular arrhythmias induced by caesium chloride in rabbits in vivo [12].
• Further studies of alinidine induced bradycardia in the presence of caesium [13].
• Most of the lipid components of hepatitis B surface antigen (HBsAg) can be removed by treatment with the non-ionic non-denaturing detergent beta-D-octyl glucoside (OG) followed by centrifugation through caesium chloride linear density gradients (density 1.15-1.32 g/ml) [14].
• Potassium channel blockers quinidine and caesium halt cell proliferation in C6 glioma cells via a polyamine-dependent mechanism [15].
• We investigated the effect of quinidine and caesium (Cs(+)) on cell proliferation, LDH (lactate dehydrogenase) release, free internal calcium, membrane potential, polyamine concentration, ODC (ornithine decarboxylase) activity and polyamine uptake in C6 glioma cells [15].

Biological context of cesium

• The caesium ions are distributed equally between the narrow and wide grooves of B DNA and are located close to the dyad axes lying between the planes of adjacent base-pairs [1].
• 8. Baclofen did not reduce the duration of action potentials that were prolonged with intracellular injections of caesium ions or by superfusions with medium that contained 10 mM-tetraethylammonium (TEA).(ABSTRACT TRUNCATED AT 400 WORDS)[16]
• Extracellular caesium ions were used to linearize the membrane properties of PCs near the resting potential [17].
• 6. The infusion of caesium resulted in a depression of the glomerular filtration rate (G.F.R.) which was not observed when the other alkali ions were infused [18].
• Highly repeated, or satellite, DNA fractions have been isolated from total Triturus cristatus carnifex DNA by renaturation kinetics, caesium salt centrifugation and restriction endonuclease digestion [19].

Anatomical context of cesium

• Cesium-133 NMR studies have been carried out on suspended human erythrocytes and on perfused rat hearts in media containing CsCl [20].
• 4. L-type Ca2+ current (ICa(L)) measured in caesium-loaded myocytes (35 C) from male and female rats of 3, 6 and 9 months of age exhibited similar characteristics [21].
• The voltage-dependent block of ATP-sensitive potassium channels of frog skeletal muscle by caesium and barium ions [22].
• Current-voltage relations have been measured for the fluxes of caesium ions through pores formed by gramicidin in lipid bilayer membranes [23].
• Their diastolic depolarisation (ranging from -60 to -35 mV) was not affected by concentrations of Cs which strongly depressed the diastolic depolarisation of the B cells, even when they were hyperpolarised in the same range of potentials [24].

Associations of cesium with other chemical compounds

• Two dyskinetoplastic strains of T. equiperdum, either acriflavine-induced or spontaneously occurring, show normal amounts of kDNA (p = 1.692 g/cm3) in analytical caesium chloride, ultracentrifugation [25].
• 4. As for many K+ channels of animal cells, external caesium caused a voltage-dependent blockage of inward (but not outward) KAT1 current, whereas tetraethylammonium caused a voltage-independent block of both inward and outward KAT1 currents [26].
• Purification and caesium chloride density gradient centrifugation show that the intact PNA-binding glycoprotein has a density of greater than 1.48 g/ml, characteristic of a mucin [27].
• 1. The intracellular potassium in giant neurones of Aplysia californica was replaced with caesium by a method utilizing the ionophore nystatin [28].
• Uptake of cesium ions by human erythrocytes and perfused rat heart: a cesium-133 NMR study [20].
• A coordination polymer, [{Cs(bth)(2)P}8] (3) (bth=benzothiazol-2-yl), was obtained when the sec-phosphane 2 was allowed to react with elemental caesium in a 1:1 ratio in diethyl ether at -78 degrees C. In 3 each anion is coordinated to four caesium cations and vice versa [29].

Gene context of cesium

• The relative permeabilities (PX/PNa) were 2.3, 1.0, 1.0, 0.95, 0.72, 0.5, 0.29, 0.16, 0.04 and 0.03 for guanidinium, potassium, sodium, methylamine, caesium, dimethylamine, 2-methylethanolamine, tris(hydroxymethyl)-aminomethane, tetraethylammonium and N-methyl-D-glucamine, respectively (values for P2X2 receptor) [30].
• Design and realization of the microwave cavity in the PTB caesium atomic fountain clock CSF1 [31].
• Increasing the transmembrane potassium gradient was also without effect and none of the potassium channel blockers TEA, 4-amino pyridine (4-AP), apamin, caesium or barium affected the oxytocin current [32].
• The permeabilities for sodium, potassium and caesium are similar, consistent with the channel being a fairly non-selective cation channel [33].
• The amplitude of the SP-induced inward current varied with changes in the Na+ concentration, did not reverse at the calculated K+ or Cl- equilibrium potentials, and was not attenuated in the presence of tetrodotoxin, low Ca2+ concentration or caesium ions [34].

Analytical, diagnostic and therapeutic context of cesium

• Isopycnic-centrifugation studies in caesium chloride and in caesium sulphate on dermatan sulphate proteoglycans from bovine sclera [35].
• Intracellular caesium injected by ionophoresis through a Cs(+)-filled microelectrode blocked the fast ISH, without affecting the slow ISH [36].
• 1. The whole-cell patch clamp technique with caesium aspartate internal solution was used with single isolated cells from the longitudinal muscle layer of guinea-pig ileum, to investigate the voltage-dependent gating of ACh-induced inward current [37].
• Crystallization studies of C-methyl pyrogallarene with potassium, rubidium and caesium bromides or chlorides resulted in a hydrogen bonded molecular cage in which the alkali metal cations are eta(6) coordinated to aromatic rings via strong cation-pi interactions [38].
• The radiotherapy was given by external beam treatment to the pelvis and by an intracavitary caesium insertion [39].

References