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Gene Review

MKT1  -  Mkt1p

Saccharomyces cerevisiae S288c

Synonyms: N2302, Protein MKT1, YNL085W
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Disease relevance of MKT1

  • MKT1 is required for maintenance of K2 above 30 degrees C in strains with the L-A-HN variant of the L-A double-stranded RNA virus of Saccharomyces cerevisiae [1].

High impact information on MKT1


Biological context of MKT1

  • The recessive natural-variant mutations are not deletions as judged by Southern blots, but deletions of the MKT1 gene constructed in vitro and used to replace the normal gene surprisingly resulted in the same phenotype as that of the mkt1 natural variants, namely, a temperature-dependent maintenance of M2 double-stranded RNA [5].
  • MKT1 is dispensable for host cell growth, mating, meiosis, and spore germination [5].

Other interactions of MKT1

  • We cloned MAK11, MAK18, and MKT1 utilizing their genetic map positions [6].
  • In this work, we analyzed three Saccharomyces cerevisiae high-temperature growth (Htg) QTGs (MKT1, END3, and RHO2) [7].
  • Interestingly, while the MKT1 and END3 coding polymorphisms contribute to phenotype, it is the RHO2 3'UTR polymorphisms that are phenotypically relevant [7].
  • We report that MKT1 encodes a 92,979 Da protein with serine-rich regions and the retroviral protease signature, DTG, but with no substantial homology to proteins presently in the databases [1].

Analytical, diagnostic and therapeutic context of MKT1


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