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Gene Review:

YAH1 - Yah1p

Saccharomyces cerevisiae S288c

Synonyms: Adrenodoxin homolog, mitochondrial, Mitochondrial ferredoxin, YPL252C

Lange, H. et al., Barros, M.H. et al., Barros, M.H. et al., Mühlenhoff, U. et al., Lutz, T. et al., et al.

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High impact information on YAH1

Herein, we identify the essential ferredoxin Yah1p of Saccharomyces cerevisiae mitochondria as a central component of the Fe/S protein biosynthesis machinery [1].
A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins [1].
Depletion of Yah1p by regulated gene expression resulted in a 30-fold accumulation of iron within mitochondria, similar to what has been reported for other components involved in Fe/S protein biogenesis [1].
2) The incorporation of radioactive delta-aminolevulinic acid into heme A is reduced in yah1 ts but not in the wild type after the shift to the restrictive temperature; and 3) the overexpression of Cox15p in cytochrome oxidase mutants that accumulate heme O leads to an increased mitochondrial concentration of heme A [2].
Cysteine is utilized by the cysteine desulfurase Nfs1p to release sulfan sulfur; ATP presumably reflects the function of the Hsp70 family chaperone Ssq1p; and NADH is used for reduction of the ferredoxin Yah1p involved in Fe/S protein biogenesis [3].

Biological context of YAH1

YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin [4].
Here we describe the identification of a yeast gene (YAH1) with significant homology to a mammalian enzyme, adrenodoxin, encoded in open reading frame (ORF) YPL252C [4].
Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O [5].

Anatomical context of YAH1

Yah1p was shown to be required for the assembly of Fe/S proteins both inside mitochondria and in the cytosol [1].

Associations of YAH1 with chemical compounds

Employing an assay that allowed us to monitor the conversion of the apoform of mitochondrial ferredoxin into its FeS-containing holoform, Ssq1 was demonstrated to be required for the FeS cluster assembly in mitochondria [6].

Other interactions of YAH1

In Schizosaccharomyces pombe COX15 is fused to YAH1, the yeast gene for mitochondrial ferredoxin (adrenodoxin) [5].

References

A mitochondrial ferredoxin is essential for biogenesis of cellular iron-sulfur proteins. Lange, H., Kaut, A., Kispal, G., Lill, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
Mitochondrial ferredoxin is required for heme A synthesis in Saccharomyces cerevisiae. Barros, M.H., Nobrega, F.G., Tzagoloff, A. J. Biol. Chem. (2002) [Pubmed]
Characterization of iron-sulfur protein assembly in isolated mitochondria. A requirement for ATP, NADH, and reduced iron. Mühlenhoff, U., Richhardt, N., Gerber, J., Lill, R. J. Biol. Chem. (2002) [Pubmed]
YAH1 of Saccharomyces cerevisiae: a new essential gene that codes for a protein homologous to human adrenodoxin. Barros, M.H., Nobrega, F.G. Gene (1999) [Pubmed]
Involvement of mitochondrial ferredoxin and Cox15p in hydroxylation of heme O. Barros, M.H., Carlson, C.G., Glerum, D.M., Tzagoloff, A. FEBS Lett. (2001) [Pubmed]
The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria. Lutz, T., Westermann, B., Neupert, W., Herrmann, J.M. J. Mol. Biol. (2001) [Pubmed]

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