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Gene Review

LTP1  -  Ltp1p

Saccharomyces cerevisiae S288c

Synonyms: Low molecular weight cytosolic acid phosphatase, Low molecular weight phosphotyrosine protein phosphatase, PTPase, YP9499.28C, YPR073C
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Disease relevance of LTP1

  • The yeast Ltp1 protein was expressed in Escherichia coli, purified to homogeneity, and shown to possess PTPase activity [1].
  • For instance, the virulence determinant gene, yopH, of Yersinia pseudotuberculosis encodes a PTPase [2].

High impact information on LTP1


Biological context of LTP1


Other interactions of LTP1

  • Here we show the phosphatase activity of Ltp1 on Fpr3 and we demonstrated that Tyr 184 is the residue phosphorylated on in vivo Fpr3 [5].

Analytical, diagnostic and therapeutic context of LTP1


  1. Cloning and characterization of a Saccharomyces cerevisiae gene encoding the low molecular weight protein-tyrosine phosphatase. Ostanin, K., Pokalsky, C., Wang, S., Van Etten, R.L. J. Biol. Chem. (1995) [Pubmed]
  2. Bacterial and viral protein tyrosine phosphatases. Guan, K.L., Dixon, J.E. Semin. Cell Biol. (1993) [Pubmed]
  3. Expression of the small tyrosine phosphatase (Stp1) in Saccharomyces cerevisiae: a study on protein tyrosine phosphorylation. Modesti, A., Bini, L., Carraresi, L., Magherini, F., Liberatori, S., Pallini, V., Manao, G., Pinna, L.A., Raugei, G., Ramponi, G. Electrophoresis (2001) [Pubmed]
  4. Crystal structures of a low-molecular weight protein tyrosine phosphatase from Saccharomyces cerevisiae and its complex with the substrate p-nitrophenyl phosphate. Wang, S., Tabernero, L., Zhang, M., Harms, E., Van Etten, R.L., Stauffacher, C.V. Biochemistry (2000) [Pubmed]
  5. The in vivo tyrosine phosphorylation level of yeast immunophilin Fpr3 is influenced by the LMW-PTP Ltp1. Magherini, F., Gamberi, T., Paoli, P., Marchetta, M., Biagini, M., Raugei, G., Camici, G., Ramponi, G., Modesti, A. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
  6. Site-directed mutagenesis of two aromatic residues lining the active site pocket of the yeast Ltp1. Paoli, P., Modesti, A., Magherini, F., Gamberi, T., Caselli, A., Manao, G., Raugei, G., Camici, G., Ramponi, G. Biochim. Biophys. Acta (2007) [Pubmed]
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