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Chemical Compound Review

CHEMBL369507     2-amino-3-phosphonooxy- butanoic acid

Synonyms: ACMC-1CP7S, P1003_SIGMA, ANW-26225, NSC-89296, CHEBI:402338, ...
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Disease relevance of phosphothreonine


High impact information on phosphothreonine


Biological context of phosphothreonine


Anatomical context of phosphothreonine


Associations of phosphothreonine with other chemical compounds


Gene context of phosphothreonine


Analytical, diagnostic and therapeutic context of phosphothreonine


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  2. Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation. Du, X.L., Edelstein, D., Rossetti, L., Fantus, I.G., Goldberg, H., Ziyadeh, F., Wu, J., Brownlee, M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  3. Altered phosphorylation pattern of simian virus 40 T antigen expressed in insect cells by using a baculovirus vector. Höss, A., Moarefi, I., Scheidtmann, K.H., Cisek, L.J., Corden, J.L., Dornreiter, I., Arthur, A.K., Fanning, E. J. Virol. (1990) [Pubmed]
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  6. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation. Canagarajah, B.J., Khokhlatchev, A., Cobb, M.H., Goldsmith, E.J. Cell (1997) [Pubmed]
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  10. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Montagnoli, A., Fiore, F., Eytan, E., Carrano, A.C., Draetta, G.F., Hershko, A., Pagano, M. Genes Dev. (1999) [Pubmed]
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  13. The multifunctional protein OBF1 is phosphorylated at serine and threonine residues in Saccharomyces cerevisiae. Francesconi, S.C., Eisenberg, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  14. En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. Muller, A.J., Pendergast, A.M., Parmar, K., Havlik, M.H., Rosenberg, N., Witte, O.N. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  15. Linear organization of the liver cell adhesion molecule L-CAM. Cunningham, B.A., Leutzinger, Y., Gallin, W.J., Sorkin, B.C., Edelman, G.M. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  16. Phosphorylation of light-harvesting complex II and photosystem II core proteins shows different irradiance-dependent regulation in vivo. Application of phosphothreonine antibodies to analysis of thylakoid phosphoproteins. Rintamäki, E., Salonen, M., Suoranta, U.M., Carlberg, I., Andersson, B., Aro, E.M. J. Biol. Chem. (1997) [Pubmed]
  17. The binding site for regulatory 14-3-3 protein in plant plasma membrane H+-ATPase: involvement of a region promoting phosphorylation-independent interaction in addition to the phosphorylation-dependent C-terminal end. Fuglsang, A.T., Borch, J., Bych, K., Jahn, T.P., Roepstorff, P., Palmgren, M.G. J. Biol. Chem. (2003) [Pubmed]
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  19. Lack of constitutive activity of the free kinase domain of protein kinase C zeta. Dependence on transphosphorylation of the activation loop. Smith, L., Smith, J.B. J. Biol. Chem. (2002) [Pubmed]
  20. A phosphoserine/threonine-binding pocket in AGC kinases and PDK1 mediates activation by hydrophobic motif phosphorylation. Frödin, M., Antal, T.L., Dümmler, B.A., Jensen, C.J., Deak, M., Gammeltoft, S., Biondi, R.M. EMBO J. (2002) [Pubmed]
  21. A cholesterol-regulated PP2A/HePTP complex with dual specificity ERK1/2 phosphatase activity. Wang, P.Y., Liu, P., Weng, J., Sontag, E., Anderson, R.G. EMBO J. (2003) [Pubmed]
  22. A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product. Collett, M.S., Erikson, E., Purchio, A.F., Brugge, J.S., Erikson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  23. Phosphorylation and activation of epidermal growth factor receptors in cells transformed by the src oncogene. Wasilenko, W.J., Payne, D.M., Fitzgerald, D.L., Weber, M.J. Mol. Cell. Biol. (1991) [Pubmed]
  24. Molecular evolution allows bypass of the requirement for activation loop phosphorylation of the Cdc28 cyclin-dependent kinase. Cross, F.R., Levine, K. Mol. Cell. Biol. (1998) [Pubmed]
  25. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase. Camps, M., Nichols, A., Gillieron, C., Antonsson, B., Muda, M., Chabert, C., Boschert, U., Arkinstall, S. Science (1998) [Pubmed]
  26. The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Lu, X., Bocangel, D., Nannenga, B., Yamaguchi, H., Appella, E., Donehower, L.A. Mol. Cell (2004) [Pubmed]
  27. Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae. Pike, B.L., Yongkiettrakul, S., Tsai, M.D., Heierhorst, J. Mol. Cell. Biol. (2004) [Pubmed]
  28. Ptc1, a type 2C Ser/Thr phosphatase, inactivates the HOG pathway by dephosphorylating the mitogen-activated protein kinase Hog1. Warmka, J., Hanneman, J., Lee, J., Amin, D., Ota, I. Mol. Cell. Biol. (2001) [Pubmed]
  29. Molecular motions of human cyclin-dependent kinase 2. Barrett, C.P., Noble, M.E. J. Biol. Chem. (2005) [Pubmed]
  30. Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). Payne, D.M., Rossomando, A.J., Martino, P., Erickson, A.K., Her, J.H., Shabanowitz, J., Hunt, D.F., Weber, M.J., Sturgill, T.W. EMBO J. (1991) [Pubmed]
  31. Ca2+/calmodulin-dependent protein kinase II: identification of threonine-286 as the autophosphorylation site in the alpha subunit associated with the generation of Ca2+-independent activity. Thiel, G., Czernik, A.J., Gorelick, F., Nairn, A.C., Greengard, P. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  32. Epidermal growth factor and potent phorbol tumor promoters induce epidermal growth factor receptor phosphorylation in a similar but distinctively different manner in human epidermoid carcinoma A431 cells. Iwashita, S., Fox, C.F. J. Biol. Chem. (1984) [Pubmed]
  33. Preliminary characterization of a heat-stable protein from rat adipose tissue whose phosphorylation is stimulated by insulin. Blackshear, P.J., Nemenoff, R.A., Avruch, J. Biochem. J. (1982) [Pubmed]
  34. An alternative method for a fast separation of phosphotyrosine. Muñoz, G., Marshall, S.H. Anal. Biochem. (1990) [Pubmed]
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