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Chemical Compound Review

ACMC-1CRJ2     3-aminopropanal

Synonyms: AG-F-22007, CHEBI:18090, HMDB01106, ANW-34363, AC1Q6QLH, ...
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Disease relevance of C05665


High impact information on C05665


Anatomical context of C05665

  • Cytotoxic levels of 3-aminopropanal are achieved before the onset of significant cerebral cell damage, and increase in a time-dependent manner with spreading neuronal and glial cell death [1].
  • Administration of N-2-MPG in clinically relevant doses to rats significantly reduces cerebral 3-aminopropanal-modified protein immunoreactivity and infarct volume in a standardized model of middle cerebral artery occlusion, even when the agent is administered after the onset of ischemia [2].

Associations of C05665 with other chemical compounds


Gene context of C05665

  • As the product of DAP oxidation, 3-amino-propanal (APAL) was detected by mass spectrometry and confirmed to be a potent noncompetitive inhibitor of GPAO [8].
  • In this investigation the bovine serum amine oxidase catalyzed oxidation of polyamines has been studied by HPLC analysis of dansylated reaction products with or without NaBH4 reduction and by NMR spectroscopy of the reaction products and 3-aminopropanal was found to be a major reaction product [9].


  1. Cerebral ischemia enhances polyamine oxidation: identification of enzymatically formed 3-aminopropanal as an endogenous mediator of neuronal and glial cell death. Ivanova, S., Botchkina, G.I., Al-Abed, Y., Meistrell, M., Batliwalla, F., Dubinsky, J.M., Iadecola, C., Wang, H., Gregersen, P.K., Eaton, J.W., Tracey, K.J. J. Exp. Med. (1998) [Pubmed]
  2. Neuroprotection in cerebral ischemia by neutralization of 3-aminopropanal. Ivanova, S., Batliwalla, F., Mocco, J., Kiss, S., Huang, J., Mack, W., Coon, A., Eaton, J.W., Al-Abed, Y., Gregersen, P.K., Shohami, E., Connolly, E.S., Tracey, K.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. Aldehyde load in ischemia-reperfusion brain injury: Neuroprotection by neutralization of reactive aldehydes with phenelzine. Wood, P.L., Khan, M.A., Moskal, J.R., Todd, K.G., Tanay, V.A., Baker, G. Brain Res. (2006) [Pubmed]
  4. Heterologous expression and characterization of mouse spermine oxidase. Cervelli, M., Polticelli, F., Federico, R., Mariottini, P. J. Biol. Chem. (2003) [Pubmed]
  5. Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae. White, W.H., Skatrud, P.L., Xue, Z., Toyn, J.H. Genetics (2003) [Pubmed]
  6. Neurotoxicity of reactive aldehydes: the concept of "aldehyde load" as demonstrated by neuroprotection with hydroxylamines. Wood, P.L., Khan, M.A., Kulow, S.R., Mahmood, S.A., Moskal, J.R. Brain Res. (2006) [Pubmed]
  7. Direct oxidative DNA damage, apoptosis and radio sensitivity by spermine oxidase activities in mouse neuroblastoma cells. Amendola, R., Bellini, A., Cervelli, M., Degan, P., Marcocci, L., Martini, F., Mariottini, P. Biochim. Biophys. Acta (2005) [Pubmed]
  8. A study on the reactions of plant copper amine oxidase with C3 and C4 aliphatic diamines. Sebela, M., Frébort, I., Lemr, K., Brauner, F., Pec, P. Arch. Biochem. Biophys. (2000) [Pubmed]
  9. HPLC and NMR investigation of the serum amine oxidase catalyzed oxidation of polyamines. Houen, G., Bock, K., Jensen, A.L. Acta Chem. Scand. (1994) [Pubmed]
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