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Gene Review

plcD  -  phospholipase C 4 PLCD

Mycobacterium tuberculosis H37Rv

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Disease relevance of plcD


High impact information on plcD

  • To identify Mycobacterium tuberculosis virulence factors, we integrated comparative genomics and epidemiologic data analysis to investigate the relationship between certain genomic insertions and deletions in the phospholipase-C gene D (plcD) with the clinical presentation of tuberculosis (TB) [1].
  • After controlling for the genotypes of the plcABC genes and the host-related risk factors, interruption in the plcD gene remained significantly associated with extrathoracic tuberculosis (odds ratio, 3.27; 95% confidence interval, 1.32 to 8.14) [2].
  • Seven M. tuberculosis isolates contain insertions of IS6110 elements within plcA, plcC or plcD [3].
  • This study investigates variations in plcABC and plcD genes in clinical isolates of M. tuberculosis, Mycobacterium africanum and 'Mycobacterium canettii'. Genetic polymorphisms were examined by PCR, Southern blot hybridization, sequence analysis and RT-PCR [3].
  • In 18 (7.3 %) of 245 isolates analysed, the plcD gene was interrupted by the insertion of one copy of IS6110, which in all cases was transposed in the same orientation and at the same position, 1 972 894, relative to the genome of M. bovis AF2122/97 [4].

Analytical, diagnostic and therapeutic context of plcD

  • In the present work, the existence of IS6110 insertions within plcD, the unique phospholipase C gene of M. bovis, has been investigated by PCR, Southern blot hybridization and sequencing analysis [4].


  1. Clinical relevance of Mycobacterium tuberculosis plcD gene mutations. Yang, Z., Yang, D., Kong, Y., Zhang, L., Marrs, C.F., Foxman, B., Bates, J.H., Wilson, F., Cave, M.D. Am. J. Respir. Crit. Care Med. (2005) [Pubmed]
  2. Distribution of insertion- and deletion-associated genetic polymorphisms among four Mycobacterium tuberculosis phospholipase C genes and associations with extrathoracic tuberculosis: a population-based study. Kong, Y., Cave, M.D., Yang, D., Zhang, L., Marrs, C.F., Foxman, B., Bates, J.H., Wilson, F., Mukasa, L.N., Yang, Z.H. J. Clin. Microbiol. (2005) [Pubmed]
  3. Analysis of genetic polymorphisms affecting the four phospholipase C (plc) genes in Mycobacterium tuberculosis complex clinical isolates. Viana-Niero, C., de Haas, P.E., van Soolingen, D., Leão, S.C. Microbiology (Reading, Engl.) (2004) [Pubmed]
  4. Identification of an IS6110 insertion site in plcD, the unique phospholipase C gene of Mycobacterium bovis. Viana-Niero, C., Rodriguez, C.A., Bigi, F., Zanini, M.S., Ferreira-Neto, J.S., Cataldi, A., Leão, S.C. J. Med. Microbiol. (2006) [Pubmed]
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