Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

PRPF4B - pre-mRNA processing factor 4B

Homo sapiens

Synonyms: KIAA0536, PR4H, PRP4, PRP4 kinase, PRP4 pre-mRNA-processing factor 4 homolog, ...

Bennett, E.M. et al., Huang, Y. et al., Dellaire, G. et al., Hay, D.I. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PRPF4B

Specific interaction of PRP4 and HIV-2 Gag was confirmed in in vitro and in vivo assays [1].
Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2 [1].
PRP4 is not incorporated into virus particles [1].
The interacting region of HIV-2 Gag is located in the conserved matrix and capsid domains, while both the RS (arginine-serine-rich) domain and the KS (kinase) domain of PRP4 are able to bind to HIV-2 Gag [1].

High impact information on PRPF4B

RNA interference of Caenorhabditis elegans PRP4K indicates that it is essential in metazoans [2].
We suggest that PRP4K is an essential kinase that, in association with the both U5 snRNP and N-CoR deacetylase complexes, demonstrates a possible coordination of pre-mRNA splicing with chromatin remodeling events involved in transcriptional regulation [2].
HIV-2 Gag is able to inhibit PRP4-mediated phosphorylation of the splicing factor SF2 [1].
Using a yeast two-hybrid screen of a T-cell cDNA library to identify cellular proteins that bind to the human immunodeficiency virus type 2 (HIV-2) Gag polyprotein, we identified PRP4, a serine-threonine protein kinase [1].
The primary structures of six human salivary acidic proline-rich proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f) [3].

Biological context of PRPF4B

These findings suggest that hPRP4, a CDK-like kinase related to MAPKs, may play a distinct role in signal transduction in addition to its role in mRNA processing [4].
Mitogen-activated protein kinases (MAPKs) and cyclin-dependent kinases (CDKs) are important proline-directed Ser/Thr kinases that play distinct roles in cell differentiation and proliferation. hPRP4 (pre-mRNA processing gene), a human homologue of S. pombe Prp4, is a recently isolated CDK-like kinase with homology to MAPKs [4].

Associations of PRPF4B with chemical compounds

Also, by using a more highly purified preparation, it has been found that position 50 in PRP-2 and PRP-4 is Asp, rather than Asn previously reported [3].

References

Human immunodeficiency virus type 2 Gag interacts specifically with PRP4, a serine-threonine kinase, and inhibits phosphorylation of splicing factor SF2. Bennett, E.M., Lever, A.M., Allen, J.F. J. Virol. (2004) [Pubmed]
Mammalian PRP4 kinase copurifies and interacts with components of both the U5 snRNP and the N-CoR deacetylase complexes. Dellaire, G., Makarov, E.M., Cowger, J.J., Longman, D., Sutherland, H.G., Lührmann, R., Torchia, J., Bickmore, W.A. Mol. Cell. Biol. (2002) [Pubmed]
The primary structures of six human salivary acidic proline-rich proteins (PRP-1, PRP-2, PRP-3, PRP-4, PIF-s and PIF-f). Hay, D.I., Bennick, A., Schlesinger, D.H., Minaguchi, K., Madapallimattam, G., Schluckebier, S.K. Biochem. J. (1988) [Pubmed]
Characterization of hPRP4 kinase activation: potential role in signaling. Huang, Y., Deng, T., Winston, B.W. Biochem. Biophys. Res. Commun. (2000) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PRPF4B	Gallus gallus
LOC709497	Macaca mulatta
Prpf4b	Mus musculus
PRPF4B	Pan troglodytes
Prpf4b	Rattus norvegicus

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.