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Gene Review

ECs4508  -  3-deoxy-D-manno-octulosonic-acid transferase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs4508

  • The mono-functional Kdo transferase of H. influenzae is membrane-bound, and the reaction is dependent upon a CMP-Kdo-generating system, as in E. coli [1].
  • 9. The identification of the mono-functional H. influenzae Kdo transferase, which is encoded by a KdtA homologue that displays 50% identity to its E. coli counterpart, should facilitate the mechanistic dissection of more complex multi-functional Kdo transferases, like those of E. coli and Chlamydia trachomatis [1].

High impact information on ECs4508


Chemical compound and disease context of ECs4508


Biological context of ECs4508

  • A plasmid from the Clarke and Carbon collection (Clarke, L., and Carbon, J. (1976) Cell 9, 91-99), pLC17-24, known to contain genes from the rfa region (81 min), was shown to overexpress KDO transferase activity 4-5 times and to correct the mutation when the plasmid was conjugated into the mutant strains [5].
  • Synthetic lipid A analogues varying in the acylation or phosphorylation pattern or both were tested as acceptors for the subsequent transfer of 3-deoxy-Dmanno-oct-2-ulosonic acid (Kdo) and heptose by successive action of Kdo transferase (WaaA), heptosyltransferase I (WaaC) and heptosyltransferase II (WaaF) [6].
  • GseA is similar, and in a few stretches identical, in its amino acid sequence to KdtA, an Escherichia coli Kdo transferase [7].

Associations of ECs4508 with chemical compounds


  1. A mono-functional 3-deoxy-D-manno-octulosonic acid (Kdo) transferase and a Kdo kinase in extracts of Haemophilus influenzae. White, K.A., Kaltashov, I.A., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (1997) [Pubmed]
  2. Cloning and overexpression of glycosyltransferases that generate the lipopolysaccharide core of Rhizobium leguminosarum. Kadrmas, J.L., Allaway, D., Studholme, R.E., Sullivan, J.T., Ronson, C.W., Poole, P.S., Raetz, C.R. J. Biol. Chem. (1998) [Pubmed]
  3. Inhibition of lipopolysaccharide biosynthesis and cell growth following inactivation of the kdtA gene in Escherichia coli. Belunis, C.J., Clementz, T., Carty, S.M., Raetz, C.R. J. Biol. Chem. (1995) [Pubmed]
  4. Biosynthesis of endotoxins. Purification and catalytic properties of 3-deoxy-D-manno-octulosonic acid transferase from Escherichia coli. Belunis, C.J., Raetz, C.R. J. Biol. Chem. (1992) [Pubmed]
  5. A gene coding for 3-deoxy-D-manno-octulosonic-acid transferase in Escherichia coli. Identification, mapping, cloning, and sequencing. Clementz, T., Raetz, C.R. J. Biol. Chem. (1991) [Pubmed]
  6. Comparative functional characterization in vitro of heptosyltransferase I (WaaC) and II (WaaF) from Escherichia coli. Gronow, S., Brabetz, W., Brade, H. Eur. J. Biochem. (2000) [Pubmed]
  7. Arg276 of GseA, a Chlamydia trachomatis Kdo transferase, is required for the synthesis of the chlamydial genus-specific epitope in Escherichia coli. Ekpo, P., Nano, F.E. FEMS Microbiol. Lett. (1992) [Pubmed]
  8. Biosynthesis of a structurally novel lipid A in Rhizobium leguminosarum: identification and characterization of six metabolic steps leading from UDP-GlcNAc to 3-deoxy-D-manno-2-octulosonic acid2-lipid IVA. Price, N.P., Kelly, T.M., Raetz, C.R., Carlson, R.W. J. Bacteriol. (1994) [Pubmed]
  9. Endotoxin of Neisseria meningitidis composed only of intact lipid A: inactivation of the meningococcal 3-deoxy-D-manno-octulosonic acid transferase. Tzeng, Y.L., Datta, A., Kolli, V.K., Carlson, R.W., Stephens, D.S. J. Bacteriol. (2002) [Pubmed]
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