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Gene Review

ECs3761  -  isopentenyl-diphosphate delta-isomerase

Escherichia coli O157:H7 str. Sakai

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Disease relevance of ECs3761


High impact information on ECs3761


Associations of ECs3761 with chemical compounds

  • Isopentenyl diphosphate isomerase (IPP isomerase) in many organisms and in plastids is central to isoprenoid synthesis and involves the conversion between IPP and dimethylallyl diphosphate (DMAPP) [2].

Analytical, diagnostic and therapeutic context of ECs3761


  1. Crystal structure of isopentenyl diphosphate:dimethylallyl diphosphate isomerase. Durbecq, V., Sainz, G., Oudjama, Y., Clantin, B., Bompard-Gilles, C., Tricot, C., Caillet, J., Stalon, V., Droogmans, L., Villeret, V. EMBO J. (2001) [Pubmed]
  2. Isopentenyl diphosphate isomerase deficiency in Synechocystis sp. strain PCC6803. Ershov, Y., Gantt, R.R., Cunningham, F.X., Gantt, E. FEBS Lett. (2000) [Pubmed]
  3. Open reading frame 176 in the photosynthesis gene cluster of Rhodobacter capsulatus encodes idi, a gene for isopentenyl diphosphate isomerase. Hahn, F.M., Baker, J.A., Poulter, C.D. J. Bacteriol. (1996) [Pubmed]
  4. An unusual isopentenyl diphosphate isomerase found in the mevalonate pathway gene cluster from Streptomyces sp. strain CL190. Kaneda, K., Kuzuyama, T., Takagi, M., Hayakawa, Y., Seto, H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Isoprenoid biosynthesis in higher plants and in Escherichia coli: on the branching in the methylerythritol phosphate pathway and the independent biosynthesis of isopentenyl diphosphate and dimethylallyl diphosphate. Hoeffler, J.F., Hemmerlin, A., Grosdemange-Billiard, C., Bach, T.J., Rohmer, M. Biochem. J. (2002) [Pubmed]
  6. Elucidation of a carotenoid biosynthesis gene cluster encoding a novel enzyme, 2,2'-beta-hydroxylase, from Brevundimonas sp. strain SD212 and combinatorial biosynthesis of new or rare xanthophylls. Nishida, Y., Adachi, K., Kasai, H., Shizuri, Y., Shindo, K., Sawabe, A., Komemushi, S., Miki, W., Misawa, N. Appl. Environ. Microbiol. (2005) [Pubmed]
  7. Enhanced lycopene production in Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate. Yoon, S.H., Lee, Y.M., Kim, J.E., Lee, S.H., Lee, J.H., Kim, J.Y., Jung, K.H., Shin, Y.C., Keasling, J.D., Kim, S.W. Biotechnol. Bioeng. (2006) [Pubmed]
  8. Isoprenoid synthesis in Escherichia coli. Separation and partial purification of four enzymes involved in the synthesis. Fujisaki, S., Nishino, T., Katsuki, H. J. Biochem. (1986) [Pubmed]
  9. Structural role for Tyr-104 in Escherichia coli isopentenyl-diphosphate isomerase: site-directed mutagenesis, enzymology, and protein crystallography. de Ruyck, J., Durisotti, V., Oudjama, Y., Wouters, J. J. Biol. Chem. (2006) [Pubmed]
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