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Gene Review

HHV8gp75  -  ORF K12

Human herpesvirus 8 type M

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Disease relevance of HHV8gp75

  • In situ hybridization indicated that mRNAs for v-cyclin D and kaposin, an HHV-8 latency-associated gene, were present in approximately 1% of the spindle cells in early patch lesions and approximately 60% of the spindle cells in late nodular lesions of Kaposi's sarcoma [1].
  • The KSHV miRNAs are expressed from what appears to be a single genetic locus that largely coincides with an approximately 4-kb noncoding sequence located between the KSHV v-cyclin and K12/Kaposin genes, both of which are also expressed in latently infected cells [2].
  • All transformed Rat-3 cell lines containing kaposin sequences produced high-grade, highly vascular, undifferentiated sarcomas upon subcutaneous injection of athymic nu/nu mice [3].
  • All of the ORFs present in KSHV have at least one homologue in RRV26-95 except K3 and K5 (bovine herpesvirus-4 immediate-early protein homologues), K7 (nut-1), and K12 (Kaposin) [4].

High impact information on HHV8gp75


Biological context of HHV8gp75


Anatomical context of HHV8gp75

  • More importantly, expression of kaposin protein was also detected in the PEL cell lines BCBL-1 and KS-1 [3].
  • Although there was no staining at the cell membrane of transfected cells, FACS analysis using kap-2 or Flag antibodies, under nonpermeable conditions, showed positivity [7].

Analytical, diagnostic and therapeutic context of HHV8gp75


  1. Expression of human herpesvirus 8-encoded cyclin D in Kaposi's sarcoma spindle cells. Davis, M.A., Stürzl, M.A., Blasig, C., Schreier, A., Guo, H.G., Reitz, M., Opalenik, S.R., Browning, P.J. J. Natl. Cancer Inst. (1997) [Pubmed]
  2. Kaposi's sarcoma-associated herpesvirus expresses an array of viral microRNAs in latently infected cells. Cai, X., Lu, S., Zhang, Z., Gonzalez, C.M., Damania, B., Cullen, B.R. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Identification of kaposin (open reading frame K12) as a human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) transforming gene. Muralidhar, S., Pumfery, A.M., Hassani, M., Sadaie, M.R., Kishishita, M., Brady, J.N., Doniger, J., Medveczky, P., Rosenthal, L.J. J. Virol. (1998) [Pubmed]
  4. The primary sequence of rhesus monkey rhadinovirus isolate 26-95: sequence similarities to Kaposi's sarcoma-associated herpesvirus and rhesus monkey rhadinovirus isolate 17577. Alexander, L., Denekamp, L., Knapp, A., Auerbach, M.R., Damania, B., Desrosiers, R.C. J. Virol. (2000) [Pubmed]
  5. Definition of an optimal cytotoxic T lymphocyte epitope in the latently expressed Kaposi's sarcoma-associated herpesvirus kaposin protein. Brander, C., O'Connor, P., Suscovich, T., Jones, N.G., Lee, Y., Kedes, D., Ganem, D., Martin, J., Osmond, D., Southwood, S., Sette, A., Walker, B.D., Scadden, D.T. J. Infect. Dis. (2001) [Pubmed]
  6. Mutational analysis reveals an essential role for the LXXLL motif in the transformation function of the human herpesvirus-8 oncoprotein, kaposin. Tomkowicz, B., Singh, S.P., Lai, D., Singh, A., Mahalingham, S., Joseph, J., Srivastava, S., Srinivasan, A. DNA Cell Biol. (2005) [Pubmed]
  7. Human herpesvirus-8 encoded Kaposin: subcellular localization using immunofluorescence and biochemical approaches. Tomkowicz, B., Singh, S.P., Cartas, M., Srinivasan, A. DNA Cell Biol. (2002) [Pubmed]
  8. Characterization of the human herpesvirus 8 (Kaposi's sarcoma-associated herpesvirus) oncogene, kaposin (ORF K12). Muralidhar, S., Veytsmann, G., Chandran, B., Ablashi, D., Doniger, J., Rosenthal, L.J. J. Clin. Virol. (2000) [Pubmed]
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