The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

araC  -  ara regulon transcriptional activator;...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0065, JW0063
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of araC


High impact information on araC

  • Three binding sites for AraC protein are required for autoregulation of araC in Escherichia coli [5].
  • This model presents our interpretations of activation and repression of the araBAD operon and the autoregulation of the araC gene [5].
  • Selective inactivation of AraC-binding sites on the DNA demonstrated that araO1 and araO2 are required in vivo to produce repression of araC in the presence of arabinose, whereas araI1 and araO2 are required in its absence [5].
  • The araC gene encodes a positive regulatory protein required for L-arabinose utilization in Escherichia coli [6].
  • A 3-base-pair deletion centered 60 base pairs from the transcriptional initiation site results in a mutant araC promoter that, in the absence of araC protein, reduces transcriptional activity when compared with the wild-type promoter and is unresponsive to various concentrations of intracellular cAMP in vivo [6].

Biological context of araC


Anatomical context of araC


Associations of araC with chemical compounds


  1. The occurrence of heritable Mu excisions in starving cells of Escherichia coli. Foster, P.L., Cairns, J. EMBO J. (1994) [Pubmed]
  2. Metabolite gene regulation of the L-arabinose operon in Escherichia coli with indoleacetic acid and other indole derivatives. Kline, E.L., Brown, C.S., Bankaitis, V., Montefiori, D.C., Craig, K. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  3. araB Gene and nucleotide sequence of the araC gene of Erwinia carotovora. Lei, S.P., Lin, H.C., Heffernan, L., Wilcox, G. J. Bacteriol. (1985) [Pubmed]
  4. DNA sequence of the araBAD-araC controlling region in Salmonella typhimurium LT2. Horwitz, A.H., Heffernan, L., Morandi, C., Lee, J.H., Timko, J., Wilcox, G. Gene (1981) [Pubmed]
  5. Three binding sites for AraC protein are required for autoregulation of araC in Escherichia coli. Hamilton, E.P., Lee, N. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  6. Regulation of the araC gene of Escherichia coli: catabolite repression, autoregulation, and effect on araBAD expression. Miyada, C.G., Stoltzfus, L., Wilcox, G. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  7. The araC gene of Escherichia coli: transcriptional and translational start-points and complete nucleotide sequence. Wallace, R.G., Lee, N., Fowler, A.V. Gene (1980) [Pubmed]
  8. The araC regulatory gene mRNA contains a leader sequence. Cass, L.G., Horwitz, A.H., Miyada, C.G., Greenfield, L., Wilcox, G. Mol. Gen. Genet. (1980) [Pubmed]
  9. Hyperproduction of araC protein from Escherichia coli. Schleif, R.F., Favreau, M.A. Biochemistry (1982) [Pubmed]
  10. Mechanism of araC autoregulation and the domains of two overlapping promoters, Pc and PBAD, in the L-arabinose regulatory region of Escherichia coli. Lee, N.L., Gielow, W.O., Wallace, R.G. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  11. AraC proteins with altered DNA sequence specificity which activate a mutant promoter in Escherichia coli. Francklyn, C.S., Lee, N. J. Biol. Chem. (1988) [Pubmed]
WikiGenes - Universities