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Gene Review:

SIGLEC6 - sialic acid binding Ig-like lectin 6

Homo sapiens

Synonyms: CD327, CD33 antigen-like 1, CD33L, CD33L1, CD33L2, ...

Patel, N. et al., Tsuji, K. et al., Brinkman-Van der Linden, E.C. et al., McDonald, I.R. et al., Takei, Y. et al., et al.

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Disease relevance of SIGLEC6

Sequencing and phylogenetic analysis of the 16S rRNA gene from Methylocystis sp. strain M have confirmed that it is most closely related to the type II methanotroph Methylocystis parvus OBBP, which, unlike Methylocystis sp. strain M, does not possess an sMMO [1].
The secondary structures of the 16S rRNA sequences of 'Methylocystis parvus' strain OBBP, 'Methylosinus trichosporium' strain OB3b, 'Methylosporovibrio methanica' strain 81Z and Hyphomicrobium sp. strain DM2 are similar, and these non-pigmented obligate group II methylotrophs form one tight cluster in the alpha-subdivision [2].

High impact information on SIGLEC6

The highest amino acid sequence similarity has been found with the myeloid-specific CD33 molecule and the placental CD33L1 protein [3].
Fourth, siglecs-2 (CD22), -3, -5, and -6 (obesity-binding protein 1) showed significant binding to sialyl-Tn (Neu5Acalpha2-6-GalNAc), a tumor marker associated with poor prognosis [4].
Fifth, siglec-6 is an exception among siglecs in not requiring the glycerol side chain of sialic acid for recognition [4].
We report the expression cloning of a novel leptin-binding protein of the immunoglobulin superfamily (OB-BP1) and a cross-hybridizing clone (OB-BP2) that is identical to a recently described sialic acid-binding I-type lectin called Siglec-5 [5].
The identification of OB-BP1/Siglec-6 as a Siglec family member, coupled with its restricted expression pattern, suggests that it may mediate cell-cell recognition events by interacting with sialylated glycoprotein ligands expressed on specific cell populations [5].

Biological context of SIGLEC6

We mapped CD33L by fluorescence in situ hybridization (FISH) to human chromosome 19q13.3, where the CD33 gene is also located [6].

Anatomical context of SIGLEC6

A monoclonal antibody specific for OB-BP1 confirmed high expression in the cyto- and syncytiotrophoblasts of the placenta [5].
Human tissues showed high levels of OB-BP1 mRNA in placenta and moderate expression in spleen, peripheral blood leukocytes, and small intestine [5].

Analytical, diagnostic and therapeutic context of SIGLEC6

Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta [6].

References

The soluble methane monooxygenase gene cluster of the trichloroethylene-degrading methanotroph Methylocystis sp. strain M. McDonald, I.R., Uchiyama, H., Kambe, S., Yagi, O., Murrell, J.C. Appl. Environ. Microbiol. (1997) [Pubmed]
16S ribosomal RNA sequence analysis for determination of phylogenetic relationship among methylotrophs. Tsuji, K., Tsien, H.C., Hanson, R.S., DePalma, S.R., Scholtz, R., LaRoche, S. J. Gen. Microbiol. (1990) [Pubmed]
Identification and molecular cloning of p75/AIRM1, a novel member of the sialoadhesin family that functions as an inhibitory receptor in human natural killer cells. Falco, M., Biassoni, R., Bottino, C., Vitale, M., Sivori, S., Augugliaro, R., Moretta, L., Moretta, A. J. Exp. Med. (1999) [Pubmed]
New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins. Brinkman-Van der Linden, E.C., Varki, A. J. Biol. Chem. (2000) [Pubmed]
OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. Patel, N., Brinkman-Van der Linden, E.C., Altmann, S.W., Gish, K., Balasubramanian, S., Timans, J.C., Peterson, D., Bell, M.P., Bazan, J.F., Varki, A., Kastelein, R.A. J. Biol. Chem. (1999) [Pubmed]
Molecular cloning of a novel gene similar to myeloid antigen CD33 and its specific expression in placenta. Takei, Y., Sasaki, S., Fujiwara, T., Takahashi, E., Muto, T., Nakamura, Y. Cytogenet. Cell Genet. (1997) [Pubmed]

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