The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

SIGLEC5  -  sialic acid binding Ig-like lectin 5

Homo sapiens

Synonyms: CD170, CD33 antigen-like 2, CD33L2, OB-BP2, OB-binding protein 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on SIGLEC5


Biological context of SIGLEC5


Anatomical context of SIGLEC5


Associations of SIGLEC5 with chemical compounds


Physical interactions of SIGLEC5

  • Human Siglec-5 is a sialic acid binding immunoglobulin (Ig)-like lectin (Siglec), comprising one N-terminal IgV-SET domain followed by three IgC2-SET domains, and a cytoplasmic domain with ITIM and SAP motifs which regulate cell signalling [9].

Other interactions of SIGLEC5

  • CD34+ precursor cells from peripheral blood constitutively expressed surface CD33, Siglec-5 and Siglec-10 [10].
  • Using an in vitro phosphatase assay with synthetic and recombinant forms of the cytoplasmic tail, it was shown that a double alanine mutant of Siglec-5 had weak, but significant SHP-1 activating properties similar to those of wild type, non-phosphorylated cytoplasmic tail, whereas a double phenylalanine mutant was inactive [4].
  • Third, siglec-5 binds alpha2-8-linked sialic acid, making it the siglec least specific for linkage recognition [11].
  • In this study, we applied a panel of immunologic and cell-based assays to demonstrate that GBS of several serotypes interacts in a Sia- and serotype-specific manner with certain human CD33rSiglecs, including hSiglec-9 and hSiglec-5 expressed on neutrophils and monocytes [12].
  • During in vitro myeloid differentiation of cord blood purified CD34+ cells, Siglec-5 was upregulated later than CD33 [13].

Analytical, diagnostic and therapeutic context of SIGLEC5


  1. Loss of Siglec expression on T lymphocytes during human evolution. Nguyen, D.H., Hurtado-Ziola, N., Gagneux, P., Varki, A. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Characterization of siglec-5, a novel glycoprotein expressed on myeloid cells related to CD33. Cornish, A.L., Freeman, S., Forbes, G., Ni, J., Zhang, M., Cepeda, M., Gentz, R., Augustus, M., Carter, K.C., Crocker, P.R. Blood (1998) [Pubmed]
  3. Discovery of Siglec-14, a novel sialic acid receptor undergoing concerted evolution with Siglec-5 in primates. Angata, T., Hayakawa, T., Yamanaka, M., Varki, A., Nakamura, M. FASEB J. (2006) [Pubmed]
  4. Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation. Avril, T., Freeman, S.D., Attrill, H., Clarke, R.G., Crocker, P.R. J. Biol. Chem. (2005) [Pubmed]
  5. Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes. Erickson-Miller, C.L., Freeman, S.D., Hopson, C.B., D'Alessio, K.J., Fischer, E.I., Kikly, K.K., Abrahamson, J.A., Holmes, S.D., King, A.G. Exp. Hematol. (2003) [Pubmed]
  6. OB-BP1/Siglec-6. a leptin- and sialic acid-binding protein of the immunoglobulin superfamily. Patel, N., Brinkman-Van der Linden, E.C., Altmann, S.W., Gish, K., Balasubramanian, S., Timans, J.C., Peterson, D., Bell, M.P., Bazan, J.F., Varki, A., Kastelein, R.A. J. Biol. Chem. (1999) [Pubmed]
  7. A comparative study of the asparagine-linked oligosaccharides on siglec-5, siglec-7 and siglec-8, expressed in a CHO cell line, and their contribution to ligand recognition. Freeman, S., Birrell, H.C., D'Alessio, K., Erickson-Miller, C., Kikly, K., Camilleri, P. Eur. J. Biochem. (2001) [Pubmed]
  8. Ganglioside binding pattern of CD33-related siglecs. Rapoport, E., Mikhalyov, I., Zhang, J., Crocker, P., Bovin, N. Bioorg. Med. Chem. Lett. (2003) [Pubmed]
  9. Human Siglec-5: tissue distribution, novel isoforms and domain specificities for sialic acid-dependent ligand interactions. Connolly, N.P., Jones, M., Watt, S.M. Br. J. Haematol. (2002) [Pubmed]
  10. Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells. Yokoi, H., Myers, A., Matsumoto, K., Crocker, P.R., Saito, H., Bochner, B.S. Allergy (2006) [Pubmed]
  11. New aspects of siglec binding specificities, including the significance of fucosylation and of the sialyl-Tn epitope. Sialic acid-binding immunoglobulin superfamily lectins. Brinkman-Van der Linden, E.C., Varki, A. J. Biol. Chem. (2000) [Pubmed]
  12. Group B streptococcal capsular sialic acids interact with siglecs (immunoglobulin-like lectins) on human leukocytes. Carlin, A.F., Lewis, A.L., Varki, A., Nizet, V. J. Bacteriol. (2007) [Pubmed]
  13. Identification of the CD33-related Siglec receptor, Siglec-5 (CD170), as a useful marker in both normal myelopoiesis and acute myeloid leukaemias. Virgo, P., Denning-Kendall, P.A., Erickson-Miller, C.L., Singha, S., Evely, R., Hows, J.M., Freeman, S.D. Br. J. Haematol. (2003) [Pubmed]
  14. Assignment of the human OB binding protein-2 gene (CD33L2) to chromosome 19q13.3 by radiation hybrid mapping. Kim, H.S. Cytogenet. Cell Genet. (1999) [Pubmed]
WikiGenes - Universities