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Gene Review

fic  -  stationary phase-induced protein, putative...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3349, JW3324, vhpT
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Disease relevance of fic

  • Stationary phase-specific expression of the fic gene in Escherichia coli K-12 is controlled by the rpoS gene product (sigma 38) [1].
  • The results show that in different gram-negative bacteria, stationary-phase-specific sigma factors which are structurally and functionally homologous to sigma s and are able to recognize the promoter sequences of both bolA and fic exist [2].

High impact information on fic

  • To identify the E sigma S recognition sequence, we analysed the promoter region of the fic gene, whose expression depends on E sigma S both in vivo and in vitro [3].
  • By random mutagenesis, we isolated a large number of the fic promoter mutants that had defective promoter activities in an rpoS+ strain [3].
  • RSF1010-derived plasmids carrying a fusion of a promoterless lacZ gene with the sigma s-dependent growth phase-regulated promoters of Escherichia coli, bolAp1 and fic, were constructed [2].
  • Transcriptional activation of the fic promoter in the different bacteria was growth phase dependent as in E. coli and was initiated generally during the transition to stationary phase [2].
  • Disruption of the secondary structure by mutation allowed expression of pabA from P2, as did translation of ribosomes into the fic-pabA intergenic region [4].

Chemical compound and disease context of fic


Biological context of fic


Associations of fic with chemical compounds


Other interactions of fic

  • The promoter activity of fic was confirmed by fusing fic and lacZ [5].
  • The kil gene was fused with the stationary-phase promoter of the fic gene of E. coli, and a secretion cassette (Kil-Km cassette) containing the regulated kil gene, the Km-resistance gene, and multiple cloning sites for the integration of target genes was constructed [9].


  1. Stationary phase-specific expression of the fic gene in Escherichia coli K-12 is controlled by the rpoS gene product (sigma 38). Utsumi, R., Kusafuka, S., Nakayama, T., Tanaka, K., Takayanagi, Y., Takahashi, H., Noda, M., Kawamukai, M. FEMS Microbiol. Lett. (1993) [Pubmed]
  2. Growth phase-dependent induction of stationary-phase promoters of Escherichia coli in different gram-negative bacteria. Miksch, G., Dobrowolski, P. J. Bacteriol. (1995) [Pubmed]
  3. Mode of promoter recognition by the Escherichia coli RNA polymerase holoenzyme containing the sigma S subunit: identification of the recognition sequence of the fic promoter. Hiratsu, K., Shinagawa, H., Makino, K. Mol. Microbiol. (1995) [Pubmed]
  4. Expression of Escherichia coli pabA. Tran, P.V., Nichols, B.P. J. Bacteriol. (1991) [Pubmed]
  5. Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli. Kawamukai, M., Matsuda, H., Fujii, W., Utsumi, R., Komano, T. J. Bacteriol. (1989) [Pubmed]
  6. Controlled secretion into the culture medium of a hybrid beta-glucanase by Acetobacter methanolicus mediated by the kil gene of Escherichia coli located on a Tn5-derived transposon. Miksch, G., Fiedler, E., Dobrowolski, P., Flaschel, E. Appl. Microbiol. Biotechnol. (1997) [Pubmed]
  7. Cloning of the fic-1 gene involved in cell filamentation induced by cyclic AMP and construction of a delta fic Escherichia coli strain. Kawamukai, M., Matsuda, H., Fujii, W., Nishida, T., Izumoto, Y., Himeno, M., Utsumi, R., Komano, T. J. Bacteriol. (1988) [Pubmed]
  8. Identification of a membrane protein induced concurrently with cell filamentation by cyclic AMP in an Escherichia coli K-12 fic mutant. Utsumi, R., Kawamukai, M., Obata, K., Morita, J., Himeno, M., Komano, T. J. Bacteriol. (1983) [Pubmed]
  9. The kil gene of the ColE1 plasmid of Escherichia coli controlled by a growth-phase-dependent promoter mediates the secretion of a heterologous periplasmic protein during the stationary phase. Miksch, G., Fiedler, E., Dobrowolski, P., Friehs, K. Arch. Microbiol. (1997) [Pubmed]
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