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Gene Review

pabA  -  aminodeoxychorismate synthase, subunit II

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3348, JW3323
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Disease relevance of pabA


High impact information on pabA


Chemical compound and disease context of pabA


Biological context of pabA


Associations of pabA with chemical compounds

  • The gene downstream from fic was found to be pabA (p-aminobenzoate) [10].
  • However, expression analysis using chromosomal pabA-lacZ translational fusions indicated that P1 expressed PabA at least 50-fold more efficiently than P2. pabA-dependent growth rate analysis indicates that P1 is essential and P2 is dispensable for PABA metabolism [5].
  • Anthranilate synthetase is composed of proteins encoded by the genes trp(G)D and trpE, whereas p-aminobenzoate synthetase is composed of proteins encoded by pabA and pabB [11].


  1. Expression of Escherichia coli pabA. Tran, P.V., Nichols, B.P. J. Bacteriol. (1991) [Pubmed]
  2. Nucleotide sequence of the Acinetobacter calcoaceticus trpGDC gene cluster. Kaplan, J.B., Goncharoff, P., Seibold, A.M., Nichols, B.P. Mol. Biol. Evol. (1984) [Pubmed]
  3. p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase. Ye, Q.Z., Liu, J., Walsh, C.T. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  4. Nucleotide sequence of Escherichia coli pabA and its evolutionary relationship to trp(G)D. Kaplan, J.B., Nichols, B.P. J. Mol. Biol. (1983) [Pubmed]
  5. Chromosomal organization and expression of Escherichia coli pabA. Tran, P.V., Bannor, T.A., Doktor, S.Z., Nichols, B.P. J. Bacteriol. (1990) [Pubmed]
  6. para-aminobenzoate synthesis from chorismate occurs in two steps. Nichols, B.P., Seibold, A.M., Doktor, S.Z. J. Biol. Chem. (1989) [Pubmed]
  7. p-Aminobenzoic acid and chloramphenicol biosynthesis in Streptomyces venezuelae: gene sets for a key enzyme, 4-amino-4-deoxychorismate synthase. Chang, Z., Sun, Y., He, J., Vining, L.C. Microbiology (Reading, Engl.) (2001) [Pubmed]
  8. Stationary phase-specific expression of the fic gene in Escherichia coli K-12 is controlled by the rpoS gene product (sigma 38). Utsumi, R., Kusafuka, S., Nakayama, T., Tanaka, K., Takayanagi, Y., Takahashi, H., Noda, M., Kawamukai, M. FEMS Microbiol. Lett. (1993) [Pubmed]
  9. Organization of the genes encoding p-aminobenzoic acid synthetase from Streptomyces lividans 1326. Arhin, F.F., Vining, L.C. Gene (1993) [Pubmed]
  10. Nucleotide sequences of fic and fic-1 genes involved in cell filamentation induced by cyclic AMP in Escherichia coli. Kawamukai, M., Matsuda, H., Fujii, W., Utsumi, R., Komano, T. J. Bacteriol. (1989) [Pubmed]
  11. Nucleotide sequence of Escherichia coli pabB indicates a common evolutionary origin of p-aminobenzoate synthetase and anthranilate synthetase. Goncharoff, P., Nichols, B.P. J. Bacteriol. (1984) [Pubmed]
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