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Gene Review

glpD  -  sn-glycerol-3-phosphate dehydrogenase,...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3412, JW3389, glyD
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Disease relevance of glpD


High impact information on glpD

  • In this case, the relative sensitivity of the glp operons to catabolite repression was glpTQ greater than glpFK greater than glpACB greater than glpD [3].
  • Comparison of the sequences of the repressor binding sites found in the glpTQ-glpACB control region with those operators previously described in the glpD operon allowed formulation of a consensus operator sequence which was the palindrome 5'-WATGTTCGWTAWC-GAACATW-3' (W is A or T) [4].
  • Expression of glpD is induced by G3P in the presence of the glpP gene product [2].
  • Full-length glpD transcripts can be detected only in glycerol-induced cells [2].
  • The GlpD overexpression strain showed increased tolerance to ampicillin and ofloxacin, while a strain with glpD deleted had a decreased level of persisters in the stationary state [5].

Chemical compound and disease context of glpD


Biological context of glpD


Other interactions of glpD


  1. Nucleotide sequence of the glpD gene encoding aerobic sn-glycerol 3-phosphate dehydrogenase of Escherichia coli K-12. Austin, D., Larson, T.J. J. Bacteriol. (1991) [Pubmed]
  2. An inverted repeat preceding the Bacillus subtilis glpD gene is a conditional terminator of transcription. Holmberg, C., Rutberg, L. Mol. Microbiol. (1992) [Pubmed]
  3. Structure and regulation of the glpFK operon encoding glycerol diffusion facilitator and glycerol kinase of Escherichia coli K-12. Weissenborn, D.L., Wittekindt, N., Larson, T.J. J. Biol. Chem. (1992) [Pubmed]
  4. Interaction at a distance between multiple operators controls the adjacent, divergently transcribed glpTQ-glpACB operons of Escherichia coli K-12. Larson, T.J., Cantwell, J.S., van Loo-Bhattacharya, A.T. J. Biol. Chem. (1992) [Pubmed]
  5. GlpD and PlsB participate in persister cell formation in Escherichia coli. Spoering, A.L., Vulic, M., Lewis, K. J. Bacteriol. (2006) [Pubmed]
  6. Antiterminator protein GlpP of Bacillus subtilis binds to glpD leader mRNA. Glatz, E., Persson, M., Rutberg, B. Microbiology (Reading, Engl.) (1998) [Pubmed]
  7. Cloning and characterization of the aerobic sn-glycerol-3-phosphate dehydrogenase structural gene glpD of Escherichia coli K-12. Schweizer, H., Larson, T.J. J. Bacteriol. (1987) [Pubmed]
  8. Different processing of an mRNA species in Bacillus subtilis and Escherichia coli. Persson, M., Glatz, E., Rutberg, B. J. Bacteriol. (2000) [Pubmed]
  9. Regulation of glpD and glpE gene expression by a cyclic AMP-cAMP receptor protein (cAMP-CRP) complex in Escherichia coli. Choi, Y.L., Kawase, S., Kawamukai, M., Sakai, H., Komano, T. Biochim. Biophys. Acta (1991) [Pubmed]
  10. Effect of glpT and glpD mutations on expression of the phoA gene in Escherichia coli. Rao, N.N., Roberts, M.F., Torriani, A., Yashphe, J. J. Bacteriol. (1993) [Pubmed]
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