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Gene Review

waaC  -  ADP-heptose:LPS heptosyl transferase I

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3611, JW3596, rfaC, yibC
 
 
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Disease relevance of rfaC

  • The next gene in the cluster, rfaC, encodes a product which also shows strong protein sequence homology between E. coli K-12 and S. typhimurium, as do the rfaF and rfaD genes which lie beyond it [1].
  • By interspecies complementation, a Salmonella typhimurium rfaC mutant (LPS chemotype Re) is transformed with the E. coli rfa-2+ gene, and the transformant is characterized by wild-type sensitivity to novobiocin (i.e., uninhibited growth at 600 micrograms of novobiocin per ml) and restoration of the ability to synthesize wild-type LPS structures [2].
  • Southern hybridization analysis indicated that both Campylobacter species contain a single copy of the waaC gene [3].
 

High impact information on rfaC

 

Chemical compound and disease context of rfaC

 

Biological context of rfaC

 

Associations of rfaC with chemical compounds

References

  1. Comparison of lipopolysaccharide biosynthesis genes rfaK, rfaL, rfaY, and rfaZ of Escherichia coli K-12 and Salmonella typhimurium. Klena, J.D., Pradel, E., Schnaitman, C.A. J. Bacteriol. (1992) [Pubmed]
  2. Cloning and characterization of the Escherichia coli K-12 rfa-2 (rfaC) gene, a gene required for lipopolysaccharide inner core synthesis. Chen, L., Coleman, W.G. J. Bacteriol. (1993) [Pubmed]
  3. Cloning, sequencing, and characterization of the lipopolysaccharide biosynthetic enzyme heptosyltransferase I gene (waaC) from Campylobacter jejuni and Campylobacter coli. Klena, J.D., Gray, S.A., Konkel, M.E. Gene (1998) [Pubmed]
  4. A phosphoethanolamine transferase specific for the outer 3-deoxy-D-manno-octulosonic acid residue of Escherichia coli lipopolysaccharide. Identification of the eptB gene and Ca2+ hypersensitivity of an eptB deletion mutant. Reynolds, C.M., Kalb, S.R., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2005) [Pubmed]
  5. A mannosyl transferase required for lipopolysaccharide inner core assembly in Rhizobium leguminosarum. Purification, substrate specificity, and expression in Salmonella waaC mutants. Kanipes, M.I., Ribeiro, A.A., Lin, S., Cotter, R.J., Raetz, C.R. J. Biol. Chem. (2003) [Pubmed]
  6. Cloning, sequencing, and functional analysis of three glycosyltransferases involved in the biosynthesis of the inner core region of Klebsiella pneumoniae lipopolysaccharide. Noah, C., Brabetz, W., Gronow, S., Brade, H. J. Endotoxin Res. (2001) [Pubmed]
  7. Expression of Campylobacter hyoilei lipo-oligosaccharide (LOS) antigens in Escherichia coli. Korolik, V., Fry, B.N., Alderton, M.R., van der Zeijst, B.A., Coloe, P.J. Microbiology (Reading, Engl.) (1997) [Pubmed]
 
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