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Chemical Compound Review

CHEBI:32817     (4R,5R,6R,7R)-4,5,6,7,8- pentahydroxy-2-oxo...

Synonyms: AC1L3OFK, AC1Q5RGJ, AR-1F2927, C01187, 10149-14-1, ...
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Disease relevance of 2-dehydro-3-deoxy-D-octonate


High impact information on 2-dehydro-3-deoxy-D-octonate


Chemical compound and disease context of 2-dehydro-3-deoxy-D-octonate


Biological context of 2-dehydro-3-deoxy-D-octonate


Anatomical context of 2-dehydro-3-deoxy-D-octonate


Associations of 2-dehydro-3-deoxy-D-octonate with other chemical compounds


Gene context of 2-dehydro-3-deoxy-D-octonate


Analytical, diagnostic and therapeutic context of 2-dehydro-3-deoxy-D-octonate

  • In our MALDI mass spectra, besides the [M--H](-) ions, abundant ions originating from the cleavage between the 3-deoxy-D-manno-oct-2-ulosonic acid (Kdo) unit and the lipid A moiety are always present, giving important pieces of information about the structure of the molecules analyzed [27].
  • The binding specificity of MAb E1 was characterized by direct and inhibition enzyme immunoassays, using natural LPSs from different strains and chemotypes, and synthetic analogs of LPS substructure of the 3-deoxy-D-manno-2-octulosonic acid (Kdo) and Lipid A regions [28].


  1. 3-Deoxy-D-manno-oct-2-ulosonic acid (Kdo) transferase (WaaA) and kdo kinase (KdkA) of Haemophilus influenzae are both required to complement a waaA knockout mutation of Escherichia coli. Brabetz, W., Müller-Loennies, S., Brade, H. J. Biol. Chem. (2000) [Pubmed]
  2. Biosynthesis of a novel 3-deoxy-D-manno-oct-2-ulosonic acid-containing outer core oligosaccharide in the lipopolysaccharide of Klebsiella pneumoniae. Frirdich, E., Vinogradov, E., Whitfield, C. J. Biol. Chem. (2004) [Pubmed]
  3. Yersinia pestis YrbH is a multifunctional protein required for both 3-deoxy-D-manno-oct-2-ulosonic acid biosynthesis and biofilm formation. Tan, L., Darby, C. Mol. Microbiol. (2006) [Pubmed]
  4. Characterization of a neutralizing monoclonal antibody directed at the lipopolysaccharide of Chlamydia pneumoniae. Peterson, E.M., de la Maza, L.M., Brade, L., Brade, H. Infect. Immun. (1998) [Pubmed]
  5. Cloning and mutagenesis of a serotype-specific DNA region involved in encapsulation and virulence of Actinobacillus pleuropneumoniae serotype 5a: concomitant expression of serotype 5a and 1 capsular polysaccharides in recombinant A. pleuropneumoniae serotype 1. Ward, C.K., Lawrence, M.L., Veit, H.P., Inzana, T.J. Infect. Immun. (1998) [Pubmed]
  6. Induction by lipopolysaccharide of intracellular and extracellular interleukin 1 production: analysis with synthetic models. Lasfargues, A., Ledur, A., Charon, D., Szabo, L., Chaby, R. J. Immunol. (1987) [Pubmed]
  7. The presence of a novel type of surface polysaccharide in Rhizobium meliloti requires a new fatty acid synthase-like gene cluster involved in symbiotic nodule development. Petrovics, G., Putnoky, P., Reuhs, B., Kim, J., Thorp, T.A., Noel, K.D., Carlson, R.W., Kondorosi, A. Mol. Microbiol. (1993) [Pubmed]
  8. Roles of 3-deoxy-D-manno-2-octulosonic acid transferase from Moraxella catarrhalis in lipooligosaccharide biosynthesis and virulence. Peng, D., Choudhury, B.P., Petralia, R.S., Carlson, R.W., Gu, X.X. Infect. Immun. (2005) [Pubmed]
  9. Detection by gas chromatography of 3-deoxy-D-manno-2-octulosonic acid and L-glycero-D-manno-heptose in whole cells of Neisseria elongata. Guerrant, G.O., Moss, C.W. J. Clin. Microbiol. (1986) [Pubmed]
  10. Rapid identification of Burkholderia pseudomallei by latex agglutination based on an exopolysaccharide-specific monoclonal antibody. Steinmetz, I., Reganzerowski, A., Brenneke, B., Haussler, S., Simpson, A., White, N.J. J. Clin. Microbiol. (1999) [Pubmed]
  11. Sinorhizobium meliloti strain 1021 produces a low-molecular-mass capsular polysaccharide that is a homopolymer of 3-deoxy-D-manno-oct-2-ulosonic acid harboring a phospholipid anchor. Fraysse, N., Lindner, B., Kaczynski, Z., Sharypova, L., Holst, O., Niehaus, K., Poinsot, V. Glycobiology (2005) [Pubmed]
  12. Methylation analysis of the heptose/3-deoxy-D-manno-2-octulosonic acid region (inner core) of the lipopolysaccharide from Salmonella minnesota rough mutants. Tacken, A., Rietschel, E.T., Brade, H. Carbohydr. Res. (1986) [Pubmed]
  13. Empirical 13C-n.m.r.-correlations between the Escherichia coli K 13 and LP 1092 capsular polysaccharides and model oligosaccharides containing D-ribose and 3-deoxy-D-manno-2-octulosonic acid. Neszmélyi, A., Kosma, P., Christian, R., Schulz, G., Unger, F.M. Carbohydr. Res. (1985) [Pubmed]
  14. Substitution pattern of 3-deoxy-D-manno-oct-2-ulosonic acid in bacterial lipopolysaccharides investigated by methylation analysis of whole LPS. Rybka, J., Zielińska-Kuźniarz, K., Korzeniowska-Kowal, A., Sondej, A., Gamian, A. Carbohydr. Res. (2003) [Pubmed]
  15. Structure of the core-oligosaccharide with a characteristic D-glycero-alpha-D-talo-oct-2-ulosylonate-(2-->4)-3-deoxy-D-manno-oct-2-ulosonate [alpha-Ko-(2-->4)-Kdo] disaccharide in the lipopolysaccharide from Burkholderia cepacia. Isshiki, Y., Zähringer, U., Kawahara, K. Carbohydr. Res. (2003) [Pubmed]
  16. Cloning, sequencing, and functional analysis of three glycosyltransferases involved in the biosynthesis of the inner core region of Klebsiella pneumoniae lipopolysaccharide. Noah, C., Brabetz, W., Gronow, S., Brade, H. J. Endotoxin Res. (2001) [Pubmed]
  17. A synthetic analog of the 3-deoxy-D-manno-2-octulosonic acid disaccharide moiety of rough-type endotoxins does not bind to mouse peritoneal macrophages and human monocytes. Girard, R., Pedron, T., Kosma, P., Chaby, R. Infect. Immun. (1993) [Pubmed]
  18. Interleukin-1 induction by lipopolysaccharides: structural requirements of the 3-deoxy-D-manno-2-octulosonic acid (KDO). Haeffner-Cavaillon, N., Caroff, M., Cavaillon, J.M. Mol. Immunol. (1989) [Pubmed]
  19. Engineering of a sialic acid synthesis pathway in transgenic plants by expression of bacterial Neu5Ac-synthesizing enzymes. Paccalet, T., Bardor, M., Rihouey, C., Delmas, F., Chevalier, C., D'Aoust, M.A., Faye, L., V??zina, L., Gomord, V., Lerouge, P. Plant Biotechnol. J. (2007) [Pubmed]
  20. Rhizobium fredii and Rhizobium meliloti produce 3-deoxy-D-manno-2-octulosonic acid-containing polysaccharides that are structurally analogous to group II K antigens (capsular polysaccharides) found in Escherichia coli. Reuhs, B.L., Carlson, R.W., Kim, J.S. J. Bacteriol. (1993) [Pubmed]
  21. Structural studies of endopolygalacturonase-resistant fragments of an antiulcer pectin from the roots of Bupleurum falcatum L. Hirano, M., Kiyohara, H., Matsumoto, T., Yamada, H. Carbohydr. Res. (1994) [Pubmed]
  22. Aquifex aeolicus 3-deoxy-D-manno-2-octulosonic acid 8-phosphate synthase: a new class of KDO 8-P synthase? Birck, M.R., Woodard, R.W. J. Mol. Evol. (2001) [Pubmed]
  23. Design and synthesis of peptide derivatives of a 3-deoxy-D-manno-2-octulosonic acid (KDO) analogue as novel antibacterial agents acting upon lipopolysaccharide biosynthesis. Claesson, A., Jansson, A.M., Pring, B.G., Hammond, S.M., Ekström, B. J. Med. Chem. (1987) [Pubmed]
  24. A bacteriophage-associated glycanase cleaving beta-pyranosidic linkages of 3-deoxy-D-manno-2-octulosonic acid (KDO). Altmann, F., Kwiatkowski, B., Stirm, S., März, L., Unger, F.M. Biochem. Biophys. Res. Commun. (1986) [Pubmed]
  25. Determination of the epitope specificity of monoclonal antibodies against the inner core region of bacterial lipopolysaccharides by use of 3-deoxy-D-manno-octulosonate-containing synthetic antigens. Rozalski, A., Brade, L., Kuhn, H.M., Brade, H., Kosma, P., Appelmelk, B.J., Kusumoto, S., Paulsen, H. Carbohydr. Res. (1989) [Pubmed]
  26. Physicochemical characterization of carboxymethyl lipid A derivatives in relation to biological activity. Seydel, U., Schromm, A.B., Brade, L., Gronow, S., Andrä, J., Müller, M., Koch, M.H., Fukase, K., Kataoka, M., Hashimoto, M., Kusumoto, S., Brandenburg, K. FEBS J. (2005) [Pubmed]
  27. New conditions for matrix-assisted laser desorption/ionization mass spectrometry of native bacterial R-type lipopolysaccharides. Sturiale, L., Garozzo, D., Silipo, A., Lanzetta, R., Parrilli, M., Molinaro, A. Rapid Commun. Mass Spectrom. (2005) [Pubmed]
  28. Preparation and binding specificity of a monoclonal antibody recognizing 3-deoxy-D-manno-2-octulosonic acid (Kdo) in lipopolysaccharides of Re chemotype. Pedron, T., Girard, R., Kosma, P., Chaby, R. Hybridoma (1992) [Pubmed]
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