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Gene Review:

menA - 1,4-dihydroxy-2-naphthoate...

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3922, JW3901, yiiW

Johnson, T.W. et al., Suvarna, K. et al., Young, I.G., Wallace, B.J. et al., Kobayashi, T. et al., et al.

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Disease relevance of menA

Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli [1].

High impact information on menA

We now report that E. coli mutants defective in the hemA gene or in the ubiA-menA genes markedly accumulate the reduced form of DsbA during growth under the conditions of protoheme deprivation as well as ubiquinone/menaquinone deprivation [2].
HPLC analyses show high levels of plastoquinone-9 in PS I complexes from the menA and menB mutants but not from the wild type [3].
PS I complexes isolated from the menA and menB mutant strains contain the full complement of polypeptides, show photoreduction of F(A) and F(B) at 15 K, and support 82-84% of the wild type rate of electron transfer from cytochrome c(6) to flavodoxin [3].
In the present work the presence of enzyme, 1,4-dihydroxy-2-naphthoate octaprenyltransferase, which catalyzes the conversion of 1,4-dihydroxy-2-naphthoate to demethylmenaquinone was demonstrated in cell extracts of E. coli [4].
The first class carries mutations in a gene designated menA, which was located at minute 78 on the E. coli chromosome by cotransduction with the glpK and metB genes [5].

Chemical compound and disease context of menA

Role of quinones in electron transport to oxygen and nitrate in Escherichia coli. Studies with a ubiA- menA- double quinone mutant [6].
A ubiA- menA- double quinone mutant of Escherichia coli K12 was constructed together with other isogenic strains lacking either ubiquinone or menaquinone [6].

Biological context of menA

DNA sequence analysis of the cloned insert revealed a 308-codon open reading frame (ORF), which by deletion analyses was shown to restore anaerobic growth of a menA mutant [1].
The menA gene encoding this enzyme has been cloned and localized to a 2.0-kb region of the Escherichia coli genome between cytR and glpK [1].
Genotypes corresponding to the menA, B, C, D, and possibly E genes described in E. coli were all identified [7].

Associations of menA with chemical compounds

It was also shown that menA- and menB- strains accumulate 1,4-dihydroxy-2-naphthoic acid and 2-succinylbenzoic acid, respectively, in their culture supernatants [5].

References

Menaquinone (vitamin K2) biosynthesis: localization and characterization of the menA gene from Escherichia coli. Suvarna, K., Stevenson, D., Meganathan, R., Hudspeth, M.E. J. Bacteriol. (1998) [Pubmed]
Respiratory chain is required to maintain oxidized states of the DsbA-DsbB disulfide bond formation system in aerobically growing Escherichia coli cells. Kobayashi, T., Kishigami, S., Sone, M., Inokuchi, H., Mogi, T., Ito, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Recruitment of a foreign quinone into the A(1) site of photosystem I. I. Genetic and physiological characterization of phylloquinone biosynthetic pathway mutants in Synechocystis sp. pcc 6803. Johnson, T.W., Shen, G., Zybailov, B., Kolling, D., Reategui, R., Beauparlant, S., Vassiliev, I.R., Bryant, D.A., Jones, A.D., Golbeck, J.H., Chitnis, P.R. J. Biol. Chem. (2000) [Pubmed]
Biosynthesis of bacterial menaquinones: the membrane-associated 1,4-dihydroxy-2-naphthoate octaprenyltransferase of Escherichia coli. Shineberg, B., Young, I.G. Biochemistry (1976) [Pubmed]
Biosynthesis of bacterial menaquinones. Menaquinone mutants of Escherichia coli. Young, I.G. Biochemistry (1975) [Pubmed]
Role of quinones in electron transport to oxygen and nitrate in Escherichia coli. Studies with a ubiA- menA- double quinone mutant. Wallace, B.J., Young, I.G. Biochim. Biophys. Acta (1977) [Pubmed]
Map locations and functions of Salmonella typhimurium men genes. Kwan, H.S., Barrett, E.L. J. Bacteriol. (1984) [Pubmed]

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