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Gene Review

metB  -  cystathionine gamma-synthase, PLP-dependent

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3931, JW3910, met-1
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Disease relevance of metB


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Biological context of metB


Associations of metB with chemical compounds


  1. Crystal structure of Escherichia coli cystathionine gamma-synthase at 1.5 A resolution. Clausen, T., Huber, R., Prade, L., Wahl, M.C., Messerschmidt, A. EMBO J. (1998) [Pubmed]
  2. Two transsulfurylation pathways in Klebsiella pneumoniae. Seiflein, T.A., Lawrence, J.G. J. Bacteriol. (2006) [Pubmed]
  3. Evolution in biosynthetic pathways: two enzymes catalyzing consecutive steps in methionine biosynthesis originate from a common ancestor and possess a similar regulatory region. Belfaiza, J., Parsot, C., Martel, A., de la Tour, C.B., Margarita, D., Cohen, G.N., Saint-Girons, I. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  4. Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria. Wheeler, P.R., Coldham, N.G., Keating, L., Gordon, S.V., Wooff, E.E., Parish, T., Hewinson, R.G. J. Biol. Chem. (2005) [Pubmed]
  5. Appendix. Purification, molecular weight, and NH2-terminal sequence of cystathionine gamma-synthase of Escherichia coli. Tran, S.V., Schaeffer, E., Bertrand, O., Mariuzza, R., Ferrara, P. J. Biol. Chem. (1983) [Pubmed]
  6. Purification and properties of cystathionine gamma-synthase from overproducing strains of Escherichia coli. Holbrook, E.L., Greene, R.C., Krueger, J.H. Biochemistry (1990) [Pubmed]
  7. Transcript analysis reveals an extended regulon and the importance of protein-protein co-operativity for the Escherichia coli methionine repressor. Marincs, F., Manfield, I.W., Stead, J.A., McDowall, K.J., Stockley, P.G. Biochem. J. (2006) [Pubmed]
  8. Escherichia coli cystathionine gamma-synthase does not obey ping-pong kinetics. Novel continuous assays for the elimination and substitution reactions. Aitken, S.M., Kim, D.H., Kirsch, J.F. Biochemistry (2003) [Pubmed]
  9. Mutagenesis and chromosome mobilization in Hyphomicrobium facilis B-522. Gliesche, C.G., Hirsch, P. Can. J. Microbiol. (1992) [Pubmed]
  10. The metIC operon involved in methionine biosynthesis in Bacillus subtilis is controlled by transcription antitermination. Auger, S., Yuen, W.H., Danchin, A., Martin-Verstraete, I. Microbiology (Reading, Engl.) (2002) [Pubmed]
  11. Directed evolution of biosynthetic pathways. Recruitment of cysteine thioethers for constructing the cell wall of Escherichia coli. Richaud, C., Mengin-Lecreulx, D., Pochet, S., Johnson, E.J., Cohen, G.N., Marlière, P. J. Biol. Chem. (1993) [Pubmed]
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