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Gene Review

iclR  -  transcriptional repressor

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK4010, JW3978
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Disease relevance of iclR


High impact information on iclR

  • These three genes are clustered, in that order, in the same acetate (ace) operon whose expression is under the transcriptional control of the iclR gene located downstream from aceK [2].
  • The purified protein was found to have a smaller mass than that predicted from the base sequence of the cloned iclR gene [3].
  • On the basis of restriction mapping followed by Southern hybridization experiments, the sor genes were mapped at 91.2 min on the chromosome, 3.3 kbp downstream of the metH-iclR gene cluster, and shown to be transcribed in a counterclockwise direction [4].
  • The iclR gene was cloned and expressed in a coupled T7 RNA polymerase/promoter system and the gene product was identified by specific binding to a fragment containing the aceBAK operator region [1].
  • Regulation of the glyoxylate bypass operon: cloning and characterization of iclR [5].

Chemical compound and disease context of iclR


Biological context of iclR


Other interactions of iclR


  1. Overproduction and characterization of the iclR gene product of Escherichia coli K-12 and comparison with that of Salmonella typhimurium LT2. Nègre, D., Cortay, J.C., Old, I.G., Galinier, A., Richaud, C., Saint Girons, I., Cozzone, A.J. Gene (1991) [Pubmed]
  2. Regulation of the acetate operon in Escherichia coli: purification and functional characterization of the IclR repressor. Cortay, J.C., Nègre, D., Galinier, A., Duclos, B., Perrière, G., Cozzone, A.J. EMBO J. (1991) [Pubmed]
  3. Preparation and properties of pure, full-length IclR protein of Escherichia coli. Use of time-of-flight mass spectrometry to investigate the problems encountered. Donald, L.J., Chernushevich, I.V., Zhou, J., Verentchikov, A., Poppe-Schriemer, N., Hosfield, D.J., Westmore, J.B., Ens, W., Duckworth, H.W., Standing, K.G. Protein Sci. (1996) [Pubmed]
  4. Cloning of the Escherichia coli sor genes for L-sorbose transport and metabolism and physical mapping of the genes near metH and iclR. Wehmeier, U.F., Nobelmann, B., Lengeler, J.W. J. Bacteriol. (1992) [Pubmed]
  5. Regulation of the glyoxylate bypass operon: cloning and characterization of iclR. Sunnarborg, A., Klumpp, D., Chung, T., LaPorte, D.C. J. Bacteriol. (1990) [Pubmed]
  6. Primary structure of the intergenic region between aceK and iclR in the Escherichia coli chromosome. Galinier, A., Bleicher, F., Nègre, D., Perrière, G., Duclos, B., Cozzone, A.J., Cortay, J.C. Gene (1991) [Pubmed]
  7. Size and sequence polymorphism in the isocitrate dehydrogenase kinase/phosphatase gene (aceK) and flanking regions in Salmonella enterica and Escherichia coli. Nelson, K., Wang, F.S., Boyd, E.F., Selander, R.K. Genetics (1997) [Pubmed]
  8. Chemostat culture characterization of Escherichia coli mutant strains metabolically engineered for aerobic succinate production: a study of the modified metabolic network based on metabolite profile, enzyme activity, and gene expression profile. Lin, H., Bennett, G.N., San, K.Y. Metab. Eng. (2005) [Pubmed]
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