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Gene Review

VPS4B  -  vacuolar protein sorting 4 homolog B (S....

Homo sapiens

Synonyms: Cell migration-inducing gene 1 protein, MIG1, Protein SKD1, SKD1, SKD1B, ...
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Disease relevance of VPS4B

  • Candidate gene analysis of BCL2, however, excludes most of this gene, except its promoter region, and draws attention to the neighboring gene VPS4B, part of the endosomal protein-sorting machinery ESCRT-III which is involved in several neurodegenerative diseases [1].
  • Finally, HIV-1 budding was inhibited by mutations in a loop that projects into the center of the modeled hVPS4B rings, suggesting that hVPS4B may release the assembled ESCRT machinery by pulling ESCRT-III substrates up into the central pore [2].

High impact information on VPS4B

  • SKD1/VPS4B is an AAA+ (ATPase associated with a variety of cellular activities) protein involved in multivesicular body (MVB) biogenesis [3].
  • SKD1(E235Q) associated with NPC1 on the endosomal membrane, whereas wild-type SKD1 associated with NPC1 only when cells were depleted of cholesterol [4].
  • Similar to the action of a mutant SKD1 protein, overexpression of a fusion derivative of human CHMP1 dilates endosomal compartments and disrupts the normal distribution of several endosomal markers [5].
  • Expression of mutant human VPS4-A (E228Q) and VPS4-B (E235Q) proteins, harbouring single amino acid exchanges in their AAA domains, induced dominant-negative vacuolar protein sorting defects in wild-type yeast cells in both cases [6].
  • The vacuolar protein sorting defect of vps4 mutant yeast cells was complemented completely by heterologous expressed human VPS4-B protein, and partially by the human VPS4-A protein [6].

Biological context of VPS4B


Other interactions of VPS4B


  1. Fine-mapping and candidate gene analysis of bovine spinal muscular atrophy. Krebs, S., Medugorac, I., Russ, I., Ossent, P., Bleul, U., Schmahl, W., Förster, M. Mamm. Genome (2006) [Pubmed]
  2. Structural and mechanistic studies of VPS4 proteins. Scott, A., Chung, H.Y., Gonciarz-Swiatek, M., Hill, G.C., Whitby, F.G., Gaspar, J., Holton, J.M., Viswanathan, R., Ghaffarian, S., Hill, C.P., Sundquist, W.I. EMBO J. (2005) [Pubmed]
  3. Interaction of the mammalian endosomal sorting complex required for transport (ESCRT) III protein hSnf7-1 with itself, membranes, and the AAA+ ATPase SKD1. Lin, Y., Kimpler, L.A., Naismith, T.V., Lauer, J.M., Hanson, P.I. J. Biol. Chem. (2005) [Pubmed]
  4. Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4. Ohsaki, Y., Sugimoto, Y., Suzuki, M., Hosokawa, H., Yoshimori, T., Davies, J.P., Ioannou, Y.A., Vanier, M.T., Ohno, K., Ninomiya, H. J. Cell. Sci. (2006) [Pubmed]
  5. CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins. Howard, T.L., Stauffer, D.R., Degnin, C.R., Hollenberg, S.M. J. Cell. Sci. (2001) [Pubmed]
  6. Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking. Scheuring, S., Röhricht, R.A., Schöning-Burkhardt, B., Beyer, A., Müller, S., Abts, H.F., Köhrer, K. J. Mol. Biol. (2001) [Pubmed]
  7. Identification of a novel mammalian member of the NSF/CDC48p/Pas1p/TBP-1 family through heterologous expression in yeast. Périer, F., Coulter, K.L., Liang, H., Radeke, C.M., Gaber, R.F., Vandenberg, C.A. FEBS Lett. (1994) [Pubmed]
  8. Comparative sequence and expression analyses of four mammalian VPS4 genes. Beyer, A., Scheuring, S., Müller, S., Mincheva, A., Lichter, P., Köhrer, K. Gene (2003) [Pubmed]
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