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Gene Review

IPO13  -  importin 13

Homo sapiens

Synonyms: IMP13, Imp13, Importin-13, KAP13, KIAA0724, ...
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Disease relevance of IPO13

  • Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase [1].

High impact information on IPO13

  • Unexpectedly, Imp13 also shows export activity towards the translation initiation factor eIF1A and is thus a case where a single importin beta-like receptor transports different substrates in opposite directions [2].
  • Importin 13: a novel mediator of nuclear import and export [2].
  • Kap13 binds to Pax6 via a nuclear localization sequence (NLS), which is located within a segment of 80 amino acid residues that includes the homeodomain [3].
  • We confirmed this hypothesis for Pax3 and Crx, which bind to and are imported by Kap13 [3].
  • Based on amino acid sequence comparisons of the encoded proteins, the KAP genes could be divided into seven high glycine-tyrosine gene families (KAP6-KAP8, and KAP19-KAP22) and four high sulfur gene families (KAP11, KAP13, KAP15, and KAP23) [4].

Biological context of IPO13

  • Following siRNA knockdown of IPO13 activity in the fetal ovary, fewer germ cells are found to progress to the late-pachytene stage of meiosis and nuclear accumulation of UBC9 is reduced [5].
  • Ipo13, which is a member of Importin-beta gene family, encodes two transcripts by utilizing different transcription start sites [5].
  • The bla(IMP-13)-containing integron and its genetic environment appeared to be similar to those found in P. aeruginosa isolates producing IMP-13 from a hospital in Rome [1].

Anatomical context of IPO13


Associations of IPO13 with chemical compounds

  • Silencing of IPO13 also abrogated the ability of cortisol to inhibit synthesis of the inflammatory cytokine IL-8 after stimulation with TNF-alpha [6].

Other interactions of IPO13

  • Ran-dependent import of Pax6 by Kap13 was shown to occur by using a digitonin-permeabilized cells assay [3].

Analytical, diagnostic and therapeutic context of IPO13

  • Of these, 25 produced either the MbetaL VIM-1 or IMP-13 as detected by PCR and sequencing [7].


  1. Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase. Pagani, L., Colinon, C., Migliavacca, R., Labonia, M., Docquier, J.D., Nucleo, E., Spalla, M., Li Bergoli, M., Rossolini, G.M. J. Clin. Microbiol. (2005) [Pubmed]
  2. Importin 13: a novel mediator of nuclear import and export. Mingot, J.M., Kostka, S., Kraft, R., Hartmann, E., Görlich, D. EMBO J. (2001) [Pubmed]
  3. Paired-type homeodomain transcription factors are imported into the nucleus by karyopherin 13. Ploski, J.E., Shamsher, M.K., Radu, A. Mol. Cell. Biol. (2004) [Pubmed]
  4. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. Rogers, M.A., Langbein, L., Winter, H., Ehmann, C., Praetzel, S., Schweizer, J. J. Biol. Chem. (2002) [Pubmed]
  5. Stage-specific Importin13 activity influences meiosis of germ cells in the mouse. Yamaguchi, Y.L., Tanaka, S.S., Yasuda, K., Matsui, Y., Tam, P.P. Dev. Biol. (2006) [Pubmed]
  6. Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells. Tao, T., Lan, J., Lukacs, G.L., Hach??, R.J., Kaplan, F. Am. J. Respir. Cell Mol. Biol. (2006) [Pubmed]
  7. Italian metallo-beta-lactamases: a national problem? Report from the SENTRY Antimicrobial Surveillance Programme. Toleman, M.A., Biedenbach, D., Bennett, D.M., Jones, R.N., Walsh, T.R. J. Antimicrob. Chemother. (2005) [Pubmed]
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