Disease relevance of IPO13

• Nosocomial outbreak caused by multidrug-resistant Pseudomonas aeruginosa producing IMP-13 metallo-beta-lactamase [1].

High impact information on IPO13

• Unexpectedly, Imp13 also shows export activity towards the translation initiation factor eIF1A and is thus a case where a single importin beta-like receptor transports different substrates in opposite directions [2].
• Importin 13: a novel mediator of nuclear import and export [2].
• Kap13 binds to Pax6 via a nuclear localization sequence (NLS), which is located within a segment of 80 amino acid residues that includes the homeodomain [3].
• We confirmed this hypothesis for Pax3 and Crx, which bind to and are imported by Kap13 [3].
• Based on amino acid sequence comparisons of the encoded proteins, the KAP genes could be divided into seven high glycine-tyrosine gene families (KAP6-KAP8, and KAP19-KAP22) and four high sulfur gene families (KAP11, KAP13, KAP15, and KAP23) [4].

Biological context of IPO13

• Following siRNA knockdown of IPO13 activity in the fetal ovary, fewer germ cells are found to progress to the late-pachytene stage of meiosis and nuclear accumulation of UBC9 is reduced [5].
• Ipo13, which is a member of Importin-beta gene family, encodes two transcripts by utilizing different transcription start sites [5].
• The bla(IMP-13)-containing integron and its genetic environment appeared to be similar to those found in P. aeruginosa isolates producing IMP-13 from a hospital in Rome [1].

Anatomical context of IPO13

• Our findings strongly implicate a stage-specific role of IPO13 in nuclear-cytoplasmic translocation of cargoes that accompanies meiotic differentiation of the mouse germ cells [5].
• The shorter transcript (TS-Ipo13) is only expressed in the germ cells in the adult testis [5].
• Importin 13 regulates nuclear import of the glucocorticoid receptor in airway epithelial cells [6].

Associations of IPO13 with chemical compounds

• Silencing of IPO13 also abrogated the ability of cortisol to inhibit synthesis of the inflammatory cytokine IL-8 after stimulation with TNF-alpha [6].

Other interactions of IPO13

• Ran-dependent import of Pax6 by Kap13 was shown to occur by using a digitonin-permeabilized cells assay [3].

Analytical, diagnostic and therapeutic context of IPO13

• Of these, 25 produced either the MbetaL VIM-1 or IMP-13 as detected by PCR and sequencing [7].

References